Bw 759u

Base Information

• Chemical Name: Bw 759u
• CAS No.: 96551-29-0
• Molecular Formula: C₉H₁₃N₅O₄
• Molecular Weight: 255.233
• Mol file: 96551-29-0.mol

Synonyms:

Chemical Property of Bw 759u

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bw 759u

There total 1 articles about Bw 759u which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine (86357-14-4) → ganciclovir (96551-29-0)

Guidance literature:

With ammonia; water; In methanol; at 25 - 30 ℃; for 48h; Product distribution / selectivity; Industry scale;

Reference yield:

ganciclovir (96551-29-0) → ethyl 2-[(5-[(2-amino-6-oxo-6,9-dihydro-1H-9-purinyl)methoxy]-2-oxo-1,3,2λ5-dioxaphosphinan-2-ylmethyl)amino]-2-phenylacetate (1473358-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran; pyridine / 2.25 h / -10 - 0 °C

2: tetrahydrofuran; pyridine / 4 h / -10 - 50 °C

With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; pyridine;

DOI:10.1007/s00044-013-0819-6

Reference yield:

ganciclovir (96551-29-0) → ethyl 2-[(5-[(2-amino-6-oxo-6,9-dihydro-1H-9-purinyl)methoxy]-2-oxo-1,3,2λ5-dioxaphosphinan-2-ylmethyl)amino] 2-(4-hydroxyphenyl)acetate (1473359-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran; pyridine / 2.25 h / -10 - 0 °C

2: tetrahydrofuran; pyridine / 4 h / -10 - 50 °C

With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; pyridine;

DOI:10.1007/s00044-013-0819-6

upstream raw materials:

9-(1,3-diacetoxy-2-propoxymethyl)-N²-acetylguanine

Downstream raw materials:

ethyl 2-[(5-[(2-amino-6-oxo-6,9-dihydro-1H-9-purinyl)methoxy]-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-ylmethyl)amino]-2-phenylacetate

ethyl 2-[(5-[(2-amino-6-oxo-6,9-dihydro-1H-9-purinyl)methoxy]-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-ylmethyl)amino] 2-(4-hydroxyphenyl)acetate

Refernces