s38093

Base Information

• Chemical Name: s38093
• CAS No.: 1222097-72-4
• Molecular Formula: C₁₇H₂₄N₂O₂*ClH
• Molecular Weight: 324.851
• Mol file: 1222097-72-4.mol

Synonyms:

Chemical Property of s38093

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

S38093 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of s38093

There total 7 articles about s38093 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide → 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide hydrochloride (1222097-72-4,1403835-46-0)

Guidance literature:

With hydrogenchloride; In water; at 20 - 60 ℃; for 2.5h; Product distribution / selectivity; Industry scale;

Reference yield: 33.0%

4-(3-Oxopropoxy)benzamide (1282993-78-5) + cis-octahydrocyclopenta[c]pyrrole hydrochloride → 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide hydrochloride (1222097-72-4,1403835-46-0)

Guidance literature:

4-(3-Oxopropoxy)benzamide; cis-octahydrocyclopenta[c]pyrrole hydrochloride; With sodium tris(acetoxy)borohydride; trimethyl orthoformate; In tetrahydrofuran; at 40 ℃; for 0.833333h;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

With hydrogenchloride; In water; isopropyl alcohol; at 40 ℃;

Reference yield:

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione (5763-44-0) → 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide hydrochloride (1222097-72-4,1403835-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / copper chromite / 1,4-dioxane / 265 °C / 153765 Torr / Industry scale

2.1: ethanol; water / 0.5 h / 0 - 20 °C

3.1: trimethyl orthoformate; sodium tris(acetoxy)borohydride / tetrahydrofuran / 0.83 h / 40 °C

3.3: 40 °C

With hydrogen; sodium tris(acetoxy)borohydride; trimethyl orthoformate; copper chromite; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

upstream raw materials:

4-(3-chloropropoxy)benzamide

p-hydroxybenzamide

4-(3,3-diethoxypropoxy)benzamide

4-(3-Oxopropoxy)benzamide

Refernces