(trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride

Base Information

• Chemical Name: (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride
• CAS No.: 1284249-22-4
• Molecular Formula: C₆H₁₁N*ClH
• Molecular Weight: 133.621
• Mol file: 1284249-22-4.mol

Synonyms:

Chemical Property of (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(1R,3S,5S)-bicyclo[3.1.0]hexan-3-aminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride

There total 3 articles about (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(trans)-bicyclo[3.1.0]hex-3-yl]-1H-isoindole-1,3(2H)-dione (1284249-21-3) → (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride (1284249-22-4,89676-80-2)

Guidance literature:

2-[(trans)-bicyclo[3.1.0]hex-3-yl]-1H-isoindole-1,3(2H)-dione; With hydrazine hydrate; In ethanol; for 16h; Reflux;

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

trans-3-Amino-bicyclo<3,1,0>hexan (79531-79-6) → (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride (1284249-22-4,89676-80-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/jm400125h

Reference yield:

(1R,3r,5S)-bicyclo[3.1.0]hexan-3-ol (694-43-9,89489-26-9) → (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride (1284249-22-4,89676-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

2: hydrazine hydrate / ethanol / 16 h / Reflux

3: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol;

DOI:10.1021/jm400125h

upstream raw materials:

2-[(trans)-bicyclo[3.1.0]hex-3-yl]-1H-isoindole-1,3(2H)-dione

trans-3-Amino-bicyclo<3,1,0>hexan

(1R,3r,5S)-bicyclo[3.1.0]hexan-3-ol

Refernces

• 1、 -. "BENZIMIDAZOLE ANTIVIRAL AGENTS". Page/Page column 70. . Retrieved 2011/09/14.