N-Hydroxylorcaserin

Base Information

• Chemical Name: N-Hydroxylorcaserin
• CAS No.: 1421747-19-4
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.691
• Mol file: 1421747-19-4.mol

Synonyms:

Chemical Property of N-Hydroxylorcaserin

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N-HydroxyLorcaserin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Hydroxy Lorcaserin is a metabolite of Lorcaserin (L469890, HCl); a novel selective 5-HT2C-receptor agonist for the treatment of obesity.

Technology Process of N-Hydroxylorcaserin

There total 3 articles about N-Hydroxylorcaserin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Lorcaserin hydrochloride (846589-98-8,1006037-59-7) → N-Hydroxylorcaserin (1421747-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium / methanol / 12 h / 55 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -78 °C / Inert atmosphere

3: dichloromethane / 25 °C / Inert atmosphere

With sodium; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; 3: |Cope Elimination;

DOI:10.1021/acs.orglett.8b03787

Reference yield:

C14H17ClN2O → N-Hydroxylorcaserin (1421747-19-4)

Guidance literature:

In dichloromethane; at 25 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03787

Reference yield:

(R)-3-(8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)propanenitrile → N-Hydroxylorcaserin (1421747-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -78 °C / Inert atmosphere

2: dichloromethane / 25 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 2: |Cope Elimination;

DOI:10.1021/acs.orglett.8b03787

upstream raw materials:

Lorcaserin hydrochloride

Refernces