Technology Process of 7-bromoisochroman-4-amine
There total 7 articles about 7-bromoisochroman-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-azido-7-bromoisochroman;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
Reflux;
With
Glauber's salt;
In
tetrahydrofuran;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium iodide; sodium hydride / tetrahydrofuran / 16 h / 20 °C / Reflux
2: potassium acetate / 2 h / Reflux
3: sodium hydroxide / ethanol / 2 h / 20 °C
4: methanol; sodium tetrahydroborate / 20 °C
5: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 17 h / 0 - 20 °C
6: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux
With
methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; diphenyl phosphoryl azide; potassium acetate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; sodium hydroxide;
In
tetrahydrofuran; ethanol; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium acetate / 2 h / Reflux
2: sodium hydroxide / ethanol / 2 h / 20 °C
3: methanol; sodium tetrahydroborate / 20 °C
4: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 17 h / 0 - 20 °C
5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux
With
methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; diphenyl phosphoryl azide; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide;
In
tetrahydrofuran; ethanol; toluene;