2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one]

Base Information

• Chemical Name: 2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one]
• CAS No.: 1255919-03-9
• Molecular Formula: C₃₈H₄₆N₁₀O₈S₂
• Molecular Weight: 834.977
• Mol file: 1255919-03-9.mol

Synonyms:

Chemical Property of 2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one]

Chemical Property:

• Boiling Point: 1034.7±75.0 °C(Predicted)
• Density: 1.49±0.1 g/cm3(Predicted)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

VardenafilDimer ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Vardenafil Dimer is a derivative compound of Vardenafil Dihydrochloride Salt (V098001) which is a selective phosphodiesterase type 5 (PDE5) inhibitor.

Technology Process of 2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one]

There total 2 articles about 2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

piperazine (110-85-0) + 4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride (224789-26-8) → 2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one] (1255919-03-9)

Guidance literature:

With triethylamine; In dichloromethane; at 25 - 30 ℃; for 0.5h;

DOI:10.1080/00397911.2011.585268

Reference yield:

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one (224789-21-3) → 2,2'-[(piperazine-1,4-disulfonyl)bis(2-ethoxy-5,1-phenylene)]-bis[5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one] (1255919-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 0 - 5 °C

2: triethylamine / dichloromethane / 0.5 h / 25 - 30 °C

With chlorosulfonic acid; triethylamine; In dichloromethane;

DOI:10.1080/00397911.2011.585268

upstream raw materials:

piperazine

4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride

2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Refernces

• 1、 Reddy, Vajrala Venkata,Naga Brahmeswara Rao, Mandava Venkata,Reddy, Ghanta Mahesh,Mukkanti, Khagga,Reddy, Ganta Madhusudhan. "Synthesis and spectral characterization of related substances of vardenafil, an erectile dysfunction drug". experimental part. p. 3513 - 3523. Retrieved 2012/10/18.