3-(aminomethyl)-5-methylhex-5-enoic acid

Base Information

• Chemical Name: 3-(aminomethyl)-5-methylhex-5-enoic acid
• CAS No.: 1141362-94-8
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.213
• Mol file: 1141362-94-8.mol

Synonyms:

Chemical Property of 3-(aminomethyl)-5-methylhex-5-enoic acid

Chemical Property:

• Boiling Point: 287.3±28.0 °C(Predicted)
• Density: 1.019±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

(S)-5,6-DehydroPregabalin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (S)-5,6-Dehydro Pregabalin is derived from rac 5,6-Dehydro Pregabalin (D230055), which is an impurity of the anti-convulsant, Pregabalin (P704800).

Technology Process of 3-(aminomethyl)-5-methylhex-5-enoic acid

There total 2 articles about 3-(aminomethyl)-5-methylhex-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid (181289-33-8) → 3-(aminomethyl)-5-methylhex-5-enoic acid (1136478-30-2,1141362-94-8) + (R,S)-3-iso-butyl-4-aminobutyric acid (128013-69-4,130912-52-6,148553-50-8,148553-51-9) + 3-(aminomethyl)-5-methylhex-4-enoic acid (216576-74-8)

Guidance literature:

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid; With sodium hydroxide; bromine; In water; at 5 - 35 ℃;

With sulfuric acid; In 2-methyl-propan-1-ol; water; at 35 ℃; pH=0.5 - 3;

With tributyl-amine; at 0 - 20 ℃; for 2 - 8h;

Reference yield:

(R,S)-3-iso-butyl-4-aminobutyric acid (128013-69-4,130912-52-6,148553-50-8,148553-51-9) → 3-(aminomethyl)-5-methylhex-5-enoic acid (1136478-30-2,1141362-94-8) + 3-(aminomethyl)-5-methylhex-4-enoic acid (216576-74-8)

Guidance literature:

(R,S)-3-iso-butyl-4-aminobutyric acid; With sodium hydroxide; bromine; In water; at 5 - 40 ℃; for 0.5h;

With sulfuric acid; In 2-methyl-propan-1-ol; water; at 30 - 33 ℃; pH=3;

With tributyl-amine; In 2-methyl-propan-1-ol; at 0 - 20 ℃; for 1h;

upstream raw materials:

(R,S)-3-iso-butyl-4-aminobutyric acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid

Refernces