21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione

Base Information

• Chemical Name: 21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione
• CAS No.: 1181-32-4
• Molecular Formula: C₂₆H₃₂ClFO₇
• Molecular Weight: 510.987
• Mol file: 1181-32-4.mol

Synonyms:

Chemical Property of 21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

21-Acetyl-6α-chlorotriamcinoloneAcetonide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 21-Acetyl-6α-chlorotriamcinolone Acetonide is an impurity of Fluocinolone Acetonide (F455800); a glucocorticoid and anti-inflammatory agent.

Technology Process of 21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione

There total 4 articles about 21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregn-4-ene-3,20-dione (2395-15-5) → 21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione (1181-32-4)

Guidance literature:

With selenium(IV) oxide;

DOI:10.1021/ja01556a085

Reference yield:

21-acetoxy-6β-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregn-4-ene-3,20-dione (4018-07-9) → 21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione (1181-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane; toluene-4-sulfonic acid / Behandeln des erhaltenen 21-Acetoxy-3-aethoxy-6-chlor-9-fluor-11β-hydroxy-16α,17-siopropylidendioxy-pregna-3,5-dien-20-ons mit wenig wss. Salzsaeure enthaltender Essigsaeure

2: selenium dioxide

With 1,4-dioxane; selenium(IV) oxide; toluene-4-sulfonic acid;

DOI:10.1021/ja01556a085

Reference yield:

16α-17-[(1-methylethylidene)bis(oxy)]-11β,21-dihydroxy-9-fluoro-4-ene-pregna-3,20-dione (1524-86-3) → 21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione (1181-32-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / Behandeln des erhaltenen 21-Acetoxy-9-fluor-11β-hydroxy-16α,17-isopropylidendioxy-pregn-4-en-3,20-dions mit Orthoameisensaeure-triaethylester, Dioxan und wenig Toluol-4-sulfonsaeure

2: acetone; aqueous sodium acetate solution; acetic acid / Reagens 4: N-Chlor-succinimid

3: dioxane; toluene-4-sulfonic acid / Behandeln des erhaltenen 21-Acetoxy-3-aethoxy-6-chlor-9-fluor-11β-hydroxy-16α,17-siopropylidendioxy-pregna-3,5-dien-20-ons mit wenig wss. Salzsaeure enthaltender Essigsaeure

4: selenium dioxide

With 1,4-dioxane; pyridine; selenium(IV) oxide; sodium acetate; toluene-4-sulfonic acid; acetic acid; acetone;

DOI:10.1021/ja01556a085

upstream raw materials:

21-acetoxy-6α-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregn-4-ene-3,20-dione

21-acetoxy-6β-chloro-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregn-4-ene-3,20-dione

16α-17-[(1-methylethylidene)bis(oxy)]-11β,21-dihydroxy-9-fluoro-4-ene-pregna-3,20-dione

21-acetoxy-3-ethoxy-9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-3,5-dien-20-one