LandiololHCL

Base Information

• Chemical Name: LandiololHCL
• CAS No.: 1253907-79-7
• Molecular Formula: C₂₅H₃₉N₃O₈*(x)ClH
• Molecular Weight: 546.06
• Mol file: 1253907-79-7.mol

Synonyms:

Chemical Property of LandiololHCL

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of LandiololHCL

There total 15 articles about LandiololHCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.9%

2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-<4-<3-<2-(morpholinocarbonylamino)ethylamino>-2S-hydroxypropoxy>phenyl>propionate (133242-30-5) → Landiolol hydrochloride (144481-98-1,1253907-79-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 5 - 10 ℃; for 2h;

Reference yield: 85.2%

[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-{4-[(2S)-2-hydroxy-3-[(2-{[(morpholin-4-yl)carbonyl]amino}ethyl)amino]propoxy]phenyl}propanoate oxalate → Landiolol hydrochloride (144481-98-1,1253907-79-7)

Guidance literature:

With pyridine hydrochloride; sodium hydroxide; In water; isopropyl alcohol; at 0 - 50 ℃; for 16h; pH=8.5; Solvent; Reagent/catalyst; Temperature;

Reference yield: 78.4%

N-(2-aminoethyl)-4-morpholine carboxamide oxalic acid (154467-16-0,947674-94-4) + [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-{4-[(2S)-2-hydroxypropoxy]phenyl}propanoate → Landiolol hydrochloride (144481-98-1,1253907-79-7)

Guidance literature:

N-(2-aminoethyl)-4-morpholine carboxamide oxalic acid; [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-{4-[(2S)-2-hydroxypropoxy]phenyl}propanoate; With sodium hydroxide; In water; isopropyl alcohol; at 30 - 40 ℃; for 8h; pH=9;

With hydrogenchloride; In ethyl acetate; pH=4 - 4.5;

upstream raw materials:

3-(4-hydroxyphenyl)propionic acid [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester

2-(morpholine-4-carboxamido)ethanamino hydrochloride

2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-<4-<3-<2-(morpholinocarbonylamino)ethylamino>-2S-hydroxypropoxy>phenyl>propionate

N-(2-aminoethyl)-4-morpholine carboxamide oxalic acid

Refernces

• 1、 -. "Preparation method of landiolol hydrochloride intermediate". Paragraph 0026. . Retrieved 2021/06/06.
• 2、 -. "Process for the enantioselective synthesis of landiolol". . . Retrieved 2018/06/28.