(R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

Base Information

• Chemical Name: (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone
• CAS No.: 1181690-72-1
• Molecular Formula: C₁₃H₁₆ClNO
• Molecular Weight: 237.729
• Mol file: 1181690-72-1.mol

Synonyms:

Chemical Property of (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

N-AcetylLorcaserin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Acetyl Lorcaserin is an impurity of Lorcaserin (L469890, HCl); a novel selective 5-HT2C-receptor agonist for the treatment of obesity. N-Acetyl Lorcaserin is also used as a reagent in the synthesis of isoquinoline, isoindoline, and benzoazepine amides as therapeutic modulators of the histamine H3 receptor.

Technology Process of (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone

There total 1 articles about (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Lorcaserin hydrochloride (846589-98-8,1006037-59-7) + acetyl chloride (75-36-5) → (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone (1181690-72-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

Lorcaserin hydrochloride

acetyl chloride

Refernces