VEGF Receptor 2 Kinase Inhibitor II

Base Information

• Chemical Name: VEGF Receptor 2 Kinase Inhibitor II
• CAS No.: 288144-20-7
• Molecular Formula: C₁₇H₁₅BrN₂O
• Molecular Weight: 343.223
• UNII: 9NPC24K8FA
• Nikkaji Number: J1.381.074E
• Wikidata: Q27089131
• Pharos Ligand ID: RAQSDJDLCGS8
• ChEMBL ID: CHEMBL88606
• Mol file: 288144-20-7.mol

Synonyms:VEGF Receptor 2 Kinase Inhibitor II;288144-20-7;Vegfr-2 inhii;Indolin-2-one deriv. 4b;VEGFR2 Kinase Inhibitor II;9NPC24K8FA;Vegfr 2 kinase inhibitor II;(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one;UNII-9NPC24K8FA;(3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one;(3Z)-5-Bromo-1,3-dihydro-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-2H-indol-2-one;2H-Indol-2-one, 5-bromo-1,3-dihydro-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-, (3Z)-;(3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one;2H-Indol-2-one, 5-bromo-1,3-dihydro-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-, (3Z)-;D00GVV;K00006;CHEMBL88606;BDBM4905;GTPL6054;SCHEMBL2196602;HMS3229O11;204003-89-4;HSCI1_000066;AKOS040755619;CCG-206806;SU-5768;BRD-K55823969-001-01-1;Q27089131;VEGFR2 Kinase Inhibitor II - CAS 288144-20-7;(z)-5-bromo-3-[(4,5,6,7-tetrahydro-1h-indol-2-yl) methylene]-1,3-dihydroindol-2-one;5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one

Chemical Property of VEGF Receptor 2 Kinase Inhibitor II

Chemical Property:

• Storage Temp.: -20C
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 342.03678
• Heavy Atom Count: 21
• Complexity: 464

Purity/Quality:

96% ^*data from raw suppliers

VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC2=C(C1)C=C(N2)C=C3C4=C(C=CC(=C4)Br)NC3=O
• Isomeric SMILES: C1CCC2=C(C1)C=C(N2)/C=C\3/C4=C(C=CC(=C4)Br)NC3=O

Technology Process of VEGF Receptor 2 Kinase Inhibitor II

There total 2 articles about VEGF Receptor 2 Kinase Inhibitor II which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-bromo-2-indolin-2-one (20870-78-4) + 4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (80744-01-0) → VEGFR receptor tyrosine kinase inhibitor II (288144-20-7)

Guidance literature:

With piperidine; In ethanol; at 95 ℃;

DOI:10.1021/jm9906116

Reference yield:

4,5,6,7-tetrahydroindole (13618-91-2) → VEGFR receptor tyrosine kinase inhibitor II (288144-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / POCl₃ / CH₂Cl₂ / 1 h / Heating

2: 99 percent / piperidine / ethanol / 95 °C

With piperidine; trichlorophosphate; In ethanol; dichloromethane; 1: Carbonylation / 2: Condensation;

DOI:10.1021/jm9906116

upstream raw materials:

5-bromo-2-indolin-2-one

4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde

4,5,6,7-tetrahydroindole

Refernces