(S)-6-methoxy-1-tetralol

Base Information

• Chemical Name: (S)-6-methoxy-1-tetralol
• CAS No.: 120523-15-1
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.231
• Mol file: 120523-15-1.mol

Synonyms:

Chemical Property of (S)-6-methoxy-1-tetralol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-methoxy-1-tetralol

There total 4 articles about (S)-6-methoxy-1-tetralol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → (S)-6-methoxy-1-tetralol (16821-32-2,42246-05-9,120523-15-1)

Guidance literature:

With Tetrahydrofurfuryl alcohol; sodium tetrahydroborate; In ethanol; chloroform; at -20 ℃; for 0.333333h;

DOI:10.1246/cl.1996.1081

Reference yield: 71.0%

C34H40O4 → (S)-6-methoxy-1-tetralol (16821-32-2,42246-05-9,120523-15-1)

Guidance literature:

With potassium hydroxide; In ethanol; Reflux;

DOI:10.1016/j.tetasy.2017.05.008

Reference yield:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → (S)-6-methoxy-1-tetralol (16821-32-2,42246-05-9,120523-15-1) + (R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:

With Tetrahydrofurfuryl alcohol; sodium tetrahydridoborate; ethanol; (S,S)-(β-oxoaldiminato)cobalt(II); In chloroform; at -20 ℃; for 6h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1246/cl.1996.737

upstream raw materials:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

Refernces

• 1、 Hayashi, Takuo,Kikuchi, Satoshi,Asano, Yukako,Endo, Yoshishige,Yamada, Tohru. "Homogeneous enantioselective catalysis in a continuous-flow microreactor: Highly enantioselective borohydride reduction of Ketones catalyzed by optically active cobalt complexes". . p. 1235 - 1240. Retrieved 2012.
• 2、 Ohkuma, Takeshi,Hattori, Tomonori,Ooka, Hirohito,Inoue, Tsutomu,Noyori, Ryoji. "BINAP/1,4-diamine-ruthenium(II) complexes for efficient asymmetric hydrogenation of 1-tetralones and analogues". . p. 2681 - 2683. Retrieved 2004.
• 3、 Matsumura, Kazuhiko,Arai, Noriyoshi,Hori, Kiyoto,Saito, Takao,Sayo, Noboru,Ohkuma, Takeshi. "Chiral ruthenabicyclic complexes: Precatalysts for rapid, enantioselective, and wide-scope hydrogenation of ketones". . p. 10696 - 10699. Retrieved 2011.
• 4、 Kolcsár, Vanessza Judit,Sz?ll?si, Gy?rgy. "Ru-catalyzed mechanochemical asymmetric transfer hydrogenations in aqueous media using chitosan as chirality source". . . Retrieved 2022/02/09.