(S)-Verapamilamide

Base Information

• Chemical Name: (S)-Verapamilamide
• CAS No.: 204642-98-8
• Molecular Formula: C₂₇H₃₆N₂O₅
• Molecular Weight: 468.593
• Mol file: 204642-98-8.mol

Synonyms:

Chemical Property of (S)-Verapamilamide

Chemical Property:

• Vapor Pressure: 3.52E-15mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

(S)-Verapamilamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A precursor for the synthesis of (S)-Verapamil A precursor for the synthesis of (S)-Verapamil.

Technology Process of (S)-Verapamilamide

There total 11 articles about (S)-Verapamilamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

N-methylhomoveratrylamine (3490-06-0) + C16H21NO4*C8H11N → (R)-verapamilamide (204642-98-8)

Guidance literature:

N-methylhomoveratrylamine; C₁₆H₂₁NO₄*C₈H₁₁N; With m-nitrobenzene boronic acid; In 5,5-dimethyl-1,3-cyclohexadiene; at 40 ℃; for 24h; Reflux;

With hydrogenchloride; sodium hydrogencarbonate; In water;

DOI:10.1021/op000059q

Reference yield: 85.5%

N-methylhomoveratrylamine (3490-06-0) + C16H21NO4*C8H11N → (S)-verapamilamide (204642-98-8)

Guidance literature:

N-methylhomoveratrylamine; C₁₆H₂₁NO₄*C₈H₁₁N; With m-nitrobenzene boronic acid; In 5,5-dimethyl-1,3-cyclohexadiene; at 40 ℃; for 24h; Reflux;

With hydrogenchloride; sodium hydrogencarbonate; In water;

DOI:10.1021/op000059q

Reference yield:

2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile (20850-49-1) → verapamilamide (204642-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium t-butanolate / tert-butyl alcohol / 3.5 h / 20 - 25 °C / Large scale

2: potassium hydroxide / ethanol; water / Large scale

3: m-nitrobenzene boronic acid / 5,5-dimethyl-1,3-cyclohexadiene / Reflux

With m-nitrobenzene boronic acid; potassium hydroxide; sodium t-butanolate; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; tert-butyl alcohol;

DOI:10.1021/op000059q

upstream raw materials:

4-(3 4-dimethoxyphenyl)-4-cyano-5-methylcapronitrile

N-methylhomoveratrylamine

4-cyano-4-(3,4-dimethoxyphenyl)-5-methyl hexanoic acid

2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile

Refernces