4'-(TRIFLUOROMETHOXY)-BIPHENYL-4-METHANAMINE

Base Information

• Chemical Name: 4'-(TRIFLUOROMETHOXY)-BIPHENYL-4-METHANAMINE
• CAS No.: 472964-25-3
• Molecular Formula: C₁₄H₁₂F₃NO
• Molecular Weight: 267.251
• Mol file: 472964-25-3.mol

Synonyms:

Chemical Property of 4'-(TRIFLUOROMETHOXY)-BIPHENYL-4-METHANAMINE

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

4'-(Trifluoromethoxy)-biphenyl-4-methanamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-(TRIFLUOROMETHOXY)-BIPHENYL-4-METHANAMINE

There total 5 articles about 4'-(TRIFLUOROMETHOXY)-BIPHENYL-4-METHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

4-Bromobenzylamine (3959-07-7) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → (4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl)methanamine (472964-25-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In acetonitrile; at 90 ℃; for 10h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.5b00176

Reference yield:

4-Bromobenzylamine (3959-07-7) → (4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl)methanamine (472964-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 0.25 h / Reflux; Inert atmosphere

1.2: Reflux; Inert atmosphere; Enzymatic reaction

1.3: 1 h / 20 °C

2.1: sodium hydroxide / water / pH 10

With potassium carbonate; sodium hydroxide; In water; acetonitrile; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;

DOI:10.1021/jm500707r

Reference yield:

4-trifluoromethoxyphenylboronic acid (139301-27-2) → (4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl)methanamine (472964-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 0.25 h / Reflux; Inert atmosphere

1.2: Reflux; Inert atmosphere; Enzymatic reaction

1.3: 1 h / 20 °C

2.1: sodium hydroxide / water / pH 10

With potassium carbonate; sodium hydroxide; In water; acetonitrile; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;

DOI:10.1021/jm500707r

upstream raw materials:

4-Bromobenzylamine

4-trifluoromethoxyphenylboronic acid

Refernces

• 1、 Tang, Jian,Wang, Bangxing,Wu, Tian,Wan, Junting,Tu, Zhengchao,Njire, Moses,Wan, Baojie,Franzblauc, Scott G.,Zhang, Tianyu,Lu, Xiaoyun,Ding, Ke. "Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents". supporting information. p. 814 - 818. Retrieved 2015/07/15.
• 2、 Lee, Hyosung,Park, Ki Duk,Yang, Xiao-Fang,Dustrude, Erik T.,Wilson, Sarah M.,Khanna, Rajesh,Kohn, Harold. "(Biphenyl-4-yl)methylammonium chlorides: Potent anticonvulsants that modulate Na+ currents". . p. 5931 - 5939. Retrieved 2013/08/23.