5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide

Base Information

• Chemical Name: 5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide
• CAS No.: 349088-89-7
• Molecular Formula: C₁₆H₁₆ClNO₂
• Molecular Weight: 289.762
• Mol file: 349088-89-7.mol

Synonyms:

Chemical Property of 5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide

Chemical Property:

Purity/Quality:

5-CHLORO-N-(2-ETHYLPHENYL)-2-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide

There total 5 articles about 5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.3%

ortho-ethylaniline (578-54-1) + 2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → 5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide (349088-89-7)

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃;

DOI:10.1016/j.tet.2016.02.035

Reference yield:

5-chloro-2-methoxybenzoic acid (3438-16-2) → 5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide (349088-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / Reflux

2: triethylamine / diethyl ether / 20 °C

With thionyl chloride; triethylamine; In diethyl ether;

DOI:10.1016/j.tet.2016.02.035

Reference yield:

2-methoxy-5-chlorobenzonitrile (55877-79-7) → 5-chloro-N-(2-ethylphenyl)-2-methoxybenzamide (349088-89-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethylene glycol / 7 h / 170 °C

2: thionyl chloride / 3 h / Reflux

3: triethylamine / diethyl ether / 20 °C

With thionyl chloride; triethylamine; potassium hydroxide; In diethyl ether; ethylene glycol;

DOI:10.1016/j.tet.2016.02.035

upstream raw materials:

ortho-ethylaniline

2-methoxy-5-chlorobenzoyl chloride

5-chloro-2-methoxybenzoic acid

2-methoxy-5-chlorobenzonitrile

Refernces