Benzoic acid, 4-(3-oxocyclohexyl)-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 4-(3-oxocyclohexyl)-, methyl ester
• CAS No.: 140483-59-6
• Molecular Formula: C14H16O3
• Molecular Weight: 232.279
• Mol file: 140483-59-6.mol

Synonyms:

Chemical Property of Benzoic acid, 4-(3-oxocyclohexyl)-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-(3-oxocyclohexyl)-, methyl ester

There total 10 articles about Benzoic acid, 4-(3-oxocyclohexyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 4-iodobenzoate (619-44-3) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → methyl 4-(3-oxocyclohexyl)benzoate (140483-59-6)

Guidance literature:

With palladium(II) trimethylacetate; silver trifluoroacetate; tris(1-methylethyl)phosphine; In 1,4-dioxane; at 80 ℃; for 24h; Schlenk technique; Glovebox; Inert atmosphere;

DOI:10.1021/ja410389a

Reference yield: 60.0%

(4-methoxyformylphenyl)(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate (1203709-73-2) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → methyl 4-(3-oxocyclohexyl)benzoate (140483-59-6)

Guidance literature:

With C₂₈H₂₈N₂O₄S₄; water; palladium diacetate; potassium trifluoroacetate; trifluoroacetic acid; In 1,4-dioxane; at 80 ℃; for 12h;

DOI:10.1039/c5sc01636c

Reference yield: 60.0%

→ methyl 4-(3-oxocyclohexyl)benzoate (140483-59-6)

Guidance literature:

With C₂₈H₂₈N₂O₄S₄; palladium diacetate; potassium trifluoroacetate; In 1,4-dioxane; water; trifluoroacetic acid; at 80 ℃; for 12h; Sealed tube;

upstream raw materials:

cyclohexenone

Methyl 4-chlorobenzoate

methyl 4-iodobenzoate

cyclohexanone

Downstream raw materials:

methyl 3'-hydroxy-[1,1'-biphenyl]-4-carboxylate

Refernces

• 1、 Casotti, Gianluca,Rositano, Vincenzo,Iuliano, Anna. "Enantioselective Conjugate Addition of Stabilized Arylzinc Iodide to Enones: an Improved Protocol of the Hayashi Reaction". . p. 1126 - 1131. Retrieved 2020/12/17.
• 2、 Hu, Xiaoyun,Yang, Xiaobo,Dai, Xi-Jie,Li, Chao-Jun. "Palladium-Catalyzed Direct β-C?H Arylation of Ketones with Arylboronic Acids in Water". supporting information. p. 2402 - 2406. Retrieved 2017/07/22.