Technology Process of Boronic acid, (2-ethylbutyl)-
There total 1 articles about Boronic acid, (2-ethylbutyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
under N2, dropwise addn. of BF3*Et2O to a suspension of NaBH4 in THF at 25°C with stirring, addn. of 2-ethyl-1-morpholino-1-butene after 1h, stirred for additional 3h at 25°C; slowly quenched with MeOH, addn. of NaOH, solvent evapn. (25°C, 12 Torr), alkaline aq. layer cooled to 0°C and acidified (concd. HCl), boronic acid extd.(ether), washed (H2O), dried (MgSO4), evapn.;
- Guidance literature:
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Multi-step reaction with 3 steps
1.1: toluene / 1 h / Inert atmosphere; Dean-Stark; Reflux
2.1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere; Sealed tube
2.2: 5 h / 20 °C / Inert atmosphere; Sealed tube
3.1: sodium hydroxide; bis(tri-tert-butylphosphine)palladium(0) / water; 1,4-dioxane / 12 h / 60 °C / Inert atmosphere; Sealed tube
With
(1,5-cyclooctadiene)(methoxy)iridium(I) dimer; bis(tri-tert-butylphosphine)palladium(0); sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; water; toluene;
DOI:10.1021/acs.orglett.9b02112