KDM5-C70

Base Information

• Chemical Name: KDM5-C70
• CAS No.: 1596348-32-1
• Molecular Formula: C₁₇H₂₈N₄O₃
• Molecular Weight: 336.434
• Mol file: 1596348-32-1.mol

Synonyms:

Chemical Property of KDM5-C70

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

KDM5-C70 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: KDOAM 21 is an inhibitor to KDM5A (Lysine Demethylase 5A) which is a protein coding gene.

Technology Process of KDM5-C70

There total 6 articles about KDM5-C70 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-N-[2-(dimethylamino)ethyl]-N-ethylacetamide + ethyl 2-formylpyridine-4-carboxylate (21908-08-7) → KDM5-C70 (1596348-32-1)

Guidance literature:

2-amino-N-[2-(dimethylamino)ethyl]-N-ethylacetamide; ethyl 2-formylpyridine-4-carboxylate; In 1,2-dichloro-ethane; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

N'-ethyl-N,N-dimethyl-1,2-ethanediamine (123-83-1) → KDM5-C70 (1596348-32-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide / N,N-dimethyl-formamide / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

3.1: 1,2-dichloro-ethane / 0.25 h / 20 °C

3.2: 20 °C

With N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

C13H27N3O3 → KDM5-C70 (1596348-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

2.1: 1,2-dichloro-ethane / 0.25 h / 20 °C

2.2: 20 °C

With trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;

upstream raw materials:

N'-ethyl-N,N-dimethyl-1,2-ethanediamine

ethyl 2-formylpyridine-4-carboxylate

pyridine-2,4-dicarboxylic acid

diethyl pyridine-2,4-dicarboxylate

Refernces

• 1、 -. "INHIBITORS OF HISTONE DEMETHYLASES". Page/Page column 93; 70. . Retrieved 2014/04/18.