N^2'-deacetyl-N^2'-(3-mercapto-1-oxopropyl)maytansine dimer

Base Information

• Chemical Name: N^2'-deacetyl-N^2'-(3-mercapto-1-oxopropyl)maytansine dimer
• CAS No.: 905449-88-9
• Molecular Formula: C₇₀H₉₄Cl₂N₆O₂₀S₂
• Molecular Weight: 1474.58
• Mol file: 905449-88-9.mol

Synonyms:

Chemical Property of N^2'-deacetyl-N^2'-(3-mercapto-1-oxopropyl)maytansine dimer

Chemical Property:

• Melting Point: >188°C (dec.)

Purity/Quality:

98% ^*data from raw suppliers

N2'',?N2''''''-?[Dithiobis(1-?oxo-?3,?1-?propanediyl)?]?bis[N2''-?deacetyl-maytansine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N2'',?N2''''''-?[Dithiobis(1-?oxo-?3,?1-?propanediyl)?]?bis[N2''-?deacetyl- maytansine is a derivative of Mertansine (M257800) which is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.

Technology Process of N^2'-deacetyl-N^2'-(3-mercapto-1-oxopropyl)maytansine dimer

There total 1 articles about N^2'-deacetyl-N^2'-(3-mercapto-1-oxopropyl)maytansine dimer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine (139504-50-0) → N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine dimer (905449-88-9)

Guidance literature:

With 2,2'-dipyridyldisulphide; In phosphate buffer; ethanol; at 20 ℃; for 2h; pH=7.5;

DOI:10.1021/jm060319f

upstream raw materials:

N^2'-deacetyl-N^2'-(3-mercapto-1-oxopropyl)maytansine

Refernces

• 1、 Widdison, Wayne C.,Wilhelm, Sharon D.,Cavanagh, Emily E.,Whiteman, Kathleen R.,Leece, Barbara A.,Kovtun, Yelena,Goldmacher, Victor S.,Xie, Hongsheng,Steeves, Rita M.,Lutz, Robert J.,Zhao, Robert,Wang, Lintao,Bl?ttler, Walter A.,Chari, Ravi V. J.. "Semisynthetic Maytansine analogues for the targeted treatment of cancer". . p. 4392 - 4408. Retrieved 2007/10/03.