1-phenyl-1H-imidazole-4-amine hydrochloride

Base Information

• Chemical Name: 1-phenyl-1H-imidazole-4-amine hydrochloride
• CAS No.: 1821666-85-6
• Molecular Formula: C₉H₉N₃*ClH
• Molecular Weight: 195.651
• Mol file: 1821666-85-6.mol

Synonyms:

Chemical Property of 1-phenyl-1H-imidazole-4-amine hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-Phenyl-1H-imidazol-4-aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-1H-imidazole-4-amine hydrochloride

There total 3 articles about 1-phenyl-1H-imidazole-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-4-nitro-1H-imidazole (41384-83-2) → 1-phenyl-1H-imidazole-4-amine hydrochloride (1821666-85-6)

Guidance literature:

1-phenyl-4-nitro-1H-imidazole; With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 5h; under 760.051 Torr;

With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.5h;

DOI:10.1002/cmdc.201500428

Reference yield:

iodobenzene (591-50-4) → 1-phenyl-1H-imidazole-4-amine hydrochloride (1821666-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 85 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 5 h / 20 °C / 760.05 Torr

2.2: 0.5 h / 20 °C

With copper(l) iodide; palladium 10% on activated carbon; hydrogen; potassium carbonate; L-proline; In ethanol; dimethyl sulfoxide;

DOI:10.1002/cmdc.201500428

Reference yield:

→ 1-phenyl-1H-imidazole-4-amine hydrochloride (1821666-85-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol;

upstream raw materials:

1-phenyl-4-nitro-1H-imidazole

iodobenzene

Refernces

• 1、 Chacón Simon, Selena,Wang, Feng,Thomas, Lance R.,Phan, Jason,Zhao, Bin,Olejniczak, Edward T.,MacDonald, Jonathan D.,Shaw, J. Grace,Schlund, Caden,Payne, William,Creighton, Joy,Stauffer, Shaun R.,Waterson, Alex G.,Tansey, William P.,Fesik, Stephen W.. "Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design". . p. 4315 - 4333. Retrieved 2020/05/25.
• 2、 Francini, Cinzia Maria,Fallacara, Anna Lucia,Artusi, Roberto,Mennuni, Laura,Calgani, Alessia,Angelucci, Adriano,Schenone, Silvia,Botta, Maurizio. "Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors". . p. 2027 - 2041. Retrieved 2015/12/23.