beclomethasone-11,17,21-tripropionate

Base Information

• Chemical Name: beclomethasone-11,17,21-tripropionate
• CAS No.: 1709825-83-1
• Molecular Formula: C₃₁H₄₁ClO₈
• Molecular Weight: 577.115
• Mol file: 1709825-83-1.mol

Synonyms:

Chemical Property of beclomethasone-11,17,21-tripropionate

Chemical Property:

• Boiling Point: 645.9±55.0 °C(Predicted)
• Density: 1.24±0.1 g/cm3(Predicted)

Purity/Quality:

92%+ ^*data from raw suppliers

Beclomethasone11,17,21-Tripropionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of beclomethasone-11,17,21-tripropionate

There total 4 articles about beclomethasone-11,17,21-tripropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

9-chloro-11β-hydroxy-16β-methyl-11,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione + propionic acid anhydride (123-62-6) → beclomethasone-11,17,21-tripropionate (1709825-83-1)

Guidance literature:

With toluene-4-sulfonic acid; trifluoroacetic acid; at 80 ℃; for 5h;

DOI:10.1016/j.steroids.2021.108948

Reference yield:

propionyl chloride (79-03-8) + beclomethasone (4419-39-0,4647-20-5) → beclomethasone-11,17,21-tripropionate (1709825-83-1)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 5 ℃; Inert atmosphere;

Reference yield:

beclomethasone (4419-39-0,4647-20-5) → beclomethasone-11,17,21-tripropionate (1709825-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2: trifluoroacetic acid; toluene-4-sulfonic acid / 5 h / 80 °C

With dmap; toluene-4-sulfonic acid; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1016/j.steroids.2021.108948

upstream raw materials:

propionyl chloride

beclomethasone

propionic acid anhydride

9β,11β-epoxy-17α,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Refernces

• 1、 -. "A dipropionate double-c ester synthesis method (by machine translation)". Paragraph 0025-0033. . Retrieved 2018/02/22.