C₁₁H₁₇N₅O₁₀P₂

Base Information

• Chemical Name: C₁₁H₁₇N₅O₁₀P₂
• CAS No.: 1359697-50-9
• Molecular Formula: C₁₁H₁₇N₅O₁₀P₂
• Molecular Weight: 441.231
• Mol file: 1359697-50-9.mol

Synonyms:

Chemical Property of C₁₁H₁₇N₅O₁₀P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₁₇N₅O₁₀P₂

There total 5 articles about C₁₁H₁₇N₅O₁₀P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

triethyl phosphate (78-40-0) + N6-methyladenosine (1867-73-8) → N6-methyl AMP (4229-50-9,49717-66-0) + C11H17N5O10P2 (1359697-50-9)

Guidance literature:

With water; trichlorophosphate; at 0 ℃;

DOI:10.1021/jm201127y

Reference yield:

2',3',5'-O-triacetyl-6-chloroinosine (5987-73-5) → N6-methyl AMP (4229-50-9,49717-66-0) + C11H17N5O10P2 (1359697-50-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol; dichloromethane / 20 - 60 °C

2: methanol; ammonia / 3 h

3: water; trichlorophosphate / 0 °C

With methanol; ammonia; water; triethylamine; trichlorophosphate; In ethanol; dichloromethane;

DOI:10.1021/jm201127y

Reference yield:

6-chloro-7H-purine (87-42-3,111055-92-6) → N6-methyl AMP (4229-50-9,49717-66-0) + C11H17N5O10P2 (1359697-50-9)

Guidance literature:

Multi-step reaction with 4 steps

1: trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 0 - 60 °C / Inert atmosphere

2: triethylamine / ethanol; dichloromethane / 20 - 60 °C

3: methanol; ammonia / 3 h

4: water; trichlorophosphate / 0 °C

With methanol; trimethylsilyl trifluoromethanesulfonate; ammonia; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trichlorophosphate; In ethanol; dichloromethane; acetonitrile;

DOI:10.1021/jm201127y

upstream raw materials:

2',3',5'-O-triacetyl-6-chloroinosine

6-N-methyladenosine 5'-acetate

triethyl phosphate

N⁶-methyladenosine

Refernces