Technology Process of (1R,2R,3S,4S,5S)-5-benzamido-2,3,4-trihydroxycyclohexanaminium 2,2,2-trifluoroacetate
There total 11 articles about (1R,2R,3S,4S,5S)-5-benzamido-2,3,4-trihydroxycyclohexanaminium 2,2,2-trifluoroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: 3-chloro-benzenecarboperoxoic acid / chloroform / 24 h / 20 °C
2: 4-methyl-morpholine; tetra-n-propylammonium perruthenate. / dichloromethane / 8 h / 20 °C / Molecular sieve
3: potassium tert-butylate; isopentyl nitrite / tetrahydrofuran / 1 h / -78 °C
4: sodium tetrahydroborate / methanol / 1 h / 0 °C
5: pyridine / tetrahydrofuran / 10 h / 0 - 20 °C
6: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 14 h / -78 - 20 °C
7: water / 24 h / 75 °C
With
4-methyl-morpholine; pyridine; sodium tetrahydroborate; tetra-n-propylammonium perruthenate.; nickel(II) chloride hexahydrate; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; isopentyl nitrite;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water;
DOI:10.1002/chem.201402175
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / methanol / 1 h / 0 °C
2: pyridine / tetrahydrofuran / 10 h / 0 - 20 °C
3: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 14 h / -78 - 20 °C
4: water / 24 h / 75 °C
With
pyridine; sodium tetrahydroborate; nickel(II) chloride hexahydrate;
In
tetrahydrofuran; methanol; water;
DOI:10.1002/chem.201402175
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4-methyl-morpholine; tetra-n-propylammonium perruthenate. / dichloromethane / 8 h / 20 °C / Molecular sieve
2: potassium tert-butylate; isopentyl nitrite / tetrahydrofuran / 1 h / -78 °C
3: sodium tetrahydroborate / methanol / 1 h / 0 °C
4: pyridine / tetrahydrofuran / 10 h / 0 - 20 °C
5: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 14 h / -78 - 20 °C
6: water / 24 h / 75 °C
With
4-methyl-morpholine; pyridine; sodium tetrahydroborate; tetra-n-propylammonium perruthenate.; nickel(II) chloride hexahydrate; potassium tert-butylate; isopentyl nitrite;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/chem.201402175