(S)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate

Base Information

• Chemical Name: (S)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate
• CAS No.: 1383787-82-3
• Molecular Formula: C₂₆H₂₆F₃NO₂
• Molecular Weight: 441.493
• Mol file: 1383787-82-3.mol

Synonyms:

Chemical Property of (S)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate

There total 4 articles about (S)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetonitrile (140-29-4) → (S)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate (1383787-82-3) + (R)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate (1383787-83-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Inert atmosphere

1.2: Inert atmosphere

1.3: Inert atmosphere; Acidic conditions

2.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: Chiralpak AD / methanol; ethanol; n-heptane / Resolution of racemate; Inert atmosphere

With n-butyllithium; In methanol; diethyl ether; ethanol; hexane; n-heptane;

DOI:10.1021/jm300611v

Reference yield:

ethyl-2-picolinate (2524-52-9,1228273-66-2) → (S)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate (1383787-82-3) + (R)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate (1383787-83-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Inert atmosphere

1.2: Inert atmosphere

1.3: Inert atmosphere; Acidic conditions

2.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: Chiralpak AD / methanol; ethanol; n-heptane / Resolution of racemate; Inert atmosphere

With n-butyllithium; In methanol; diethyl ether; ethanol; hexane; n-heptane;

DOI:10.1021/jm300611v

Reference yield:

benzyl 2-pyridyl ketone (27049-45-2) → (S)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate (1383787-82-3) + (R)-2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate (1383787-83-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: Chiralpak AD / methanol; ethanol; n-heptane / Resolution of racemate; Inert atmosphere

With n-butyllithium; In methanol; diethyl ether; ethanol; hexane; n-heptane;

DOI:10.1021/jm300611v

upstream raw materials:

ethyl-2-picolinate

benzyl 2-pyridyl ketone

2-phenyl-1-(pyridin-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl 3,3-dimethylbutanoate

phenylacetonitrile

Refernces