Technology Process of (4-ethoxy-2-carboxy-phenyl)-acetic acid
There total 5 articles about (4-ethoxy-2-carboxy-phenyl)-acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sulfuric acid; sodium nitrite / 2 h / 0 °C
1.2: Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h
With
sulfuric acid; potassium carbonate; sodium nitrite;
In
N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2016.12.036
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: nitric acid; sulfuric acid / 2 h / 0 °C
2.1: 5%-palladium/activated carbon; hydrogen / methanol
3.1: sulfuric acid; sodium nitrite / 2 h / 0 °C
3.2: Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 48 h
With
sulfuric acid; 5%-palladium/activated carbon; hydrogen; nitric acid; potassium carbonate; sodium nitrite;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2016.12.036
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 5%-palladium/activated carbon; hydrogen / methanol
2.1: sulfuric acid; sodium nitrite / 2 h / 0 °C
2.2: Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 48 h
With
sulfuric acid; 5%-palladium/activated carbon; hydrogen; potassium carbonate; sodium nitrite;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2016.12.036
