C₃₂H₃₂F₂N₄O₆

Base Information

• Chemical Name: C₃₂H₃₂F₂N₄O₆
• CAS No.: 1196509-67-7
• Molecular Formula: C₃₂H₃₂F₂N₄O₆
• Molecular Weight: 606.626
• Mol file: 1196509-67-7.mol

Synonyms:

Chemical Property of C₃₂H₃₂F₂N₄O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₂F₂N₄O₆

There total 7 articles about C₃₂H₃₂F₂N₄O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(5-iodo-1H-indazol-1-yl)benzoic acid (1034155-43-5) → C32H32F2N4O6 (1196509-67-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 - 55 °C

2.1: dimethylaminoacetic acid; caesium carbonate; copper(l) iodide / 0.5 h / 110 °C

2.2: 19 h / 110 °C / Sealed tube

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 2.5 h / 20 °C

4.1: lithium hydroxide / methanol; water; tetrahydrofuran / 3 h

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With copper(l) iodide; dimethylaminoacetic acid; sodium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: |Ullmann Condensation / 2.2: |Ullmann Condensation;

DOI:10.1021/acs.jmedchem.7b01215

Reference yield:

3-hydrazinobenzoic acid (38235-71-1) → C32H32F2N4O6 (1196509-67-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1.33 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 0.5 h / 160 °C

3.1: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 - 55 °C

4.1: dimethylaminoacetic acid; caesium carbonate; copper(l) iodide / 0.5 h / 110 °C

4.2: 19 h / 110 °C / Sealed tube

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 2.5 h / 20 °C

6.1: lithium hydroxide / methanol; water; tetrahydrofuran / 3 h

7.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With copper(l) iodide; dimethylaminoacetic acid; potassium tert-butylate; sodium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: |Ullmann Condensation / 4.2: |Ullmann Condensation;

DOI:10.1021/acs.jmedchem.7b01215

Reference yield:

2-Fluoro-5-iodo-benzaldehyde (146137-76-0) → C32H32F2N4O6 (1196509-67-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1.33 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 0.5 h / 160 °C

3.1: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 - 55 °C

4.1: dimethylaminoacetic acid; caesium carbonate; copper(l) iodide / 0.5 h / 110 °C

4.2: 19 h / 110 °C / Sealed tube

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 2.5 h / 20 °C

6.1: lithium hydroxide / methanol; water; tetrahydrofuran / 3 h

7.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With copper(l) iodide; dimethylaminoacetic acid; potassium tert-butylate; sodium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: |Ullmann Condensation / 4.2: |Ullmann Condensation;

DOI:10.1021/acs.jmedchem.7b01215

upstream raw materials:

3-(5-iodo-1H-indazol-1-yl)benzoic acid

(3S)-tetrahydrofuran-3-amine hydrochloride

2-Fluoro-5-iodo-benzaldehyde

3-hydrazinobenzoic acid

Refernces