CYCLOHEXANEMETHANOL, 1-METHANSULFONATE

Base Information

• Chemical Name: CYCLOHEXANEMETHANOL, 1-METHANSULFONATE
• CAS No.: 14100-97-1
• Molecular Formula: C8H16O3S
• Molecular Weight: 192.279
• Hs Code.: 2930909899
• Mol file: 14100-97-1.mol

Synonyms:Cyclohexanemethyl isothiocyanate;cyclohexylmethanisothiocyanate;cyclohexylmethylisothiocyanate;1-isothiocyanatomethyl-cyclohexane;Cyclohexyl-methylisothiocyanat;Cyclohexanmethyl-methansulfonat;cyclohexylmethyl mesylate;Methanesulfonic acid cyclohexylmethyl ester;

Chemical Property of CYCLOHEXANEMETHANOL, 1-METHANSULFONATE

Chemical Property:

• Boiling Point: 316.9±11.0 °C(Predicted)
• PSA: 51.75000
• Density: 1.121±0.06 g/cm3(Predicted)
• LogP: 2.62370

Purity/Quality:

99%, ^*data from raw suppliers

CyclohexylmethylMesylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cyclohexylmethyl Mesylate is a reactant used in the preparation of (adamantanylureido)cyclohexanol derivatives as orally bioavailable potent soluble epoxide hydrolase inhibitors.

Technology Process of CYCLOHEXANEMETHANOL, 1-METHANSULFONATE

There total 2 articles about CYCLOHEXANEMETHANOL, 1-METHANSULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanesulfonyl chloride (124-63-0) + cyclohexylmethyl alcohol (100-49-2) → cyclohexylmethyl methanesulfonate (14100-97-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere;

Reference yield: 89.0%

→ cyclohexylmethyl methanesulfonate (14100-97-1)

Guidance literature:

With triethylamine; In tert-butyl methyl ether; at 0 - 20 ℃; for 2h;

Reference yield: 93.0%

cyclohexylmethyl methanesulfonate (14100-97-1) + methyl (5Z)-7-(3-exo-(hydroxymethyl)-7-oxabicyclo<2.2.1>heptan-2-exo-yl)hept-5-enoate (104596-10-3) → (Z)-7-((1S,2R,3R,4R)-3-Cyclohexylmethoxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid cyclohexylmethyl ester

Guidance literature:

With potassium hydroxide; In xylene; for 5h; Heating;

DOI:10.1021/jm00161a032

upstream raw materials:

methanesulfonyl chloride

cyclohexylmethyl alcohol

Downstream raw materials:

(cyclohexylmethyl)(phenyl)sulfide

cyclohexylmethyl iodide

4-cyclohexylmethoxy-2-hydroxyacetophenone

1-(2-(cyclohexylmethoxy)-6-hydroxyphenyl)ethanone

Refernces

• 1、 Gilles, Philippe,Kashyap, Rudra S.,Freitas, Maria Jo?o,Ceusters, Sam,Van Asch, Koen,Janssens, Anke,De Jonghe, Steven,Persoons, Leentje,Cobbaut, Mathias,Daelemans, Dirk,Van Lint, Johan,Voet, Arnout R.D.,De Borggraeve, Wim M.. "Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors". supporting information. . Retrieved 2020/08/25.
• 2、 -. "MITOCHONDRIA-TARGETING PEPTIDES". Page/Page column 52; 53. . Retrieved 2019/07/19.