1-(4-Piperidyl)-1,2,3,4-tetrahydro-2-quinolinone hydrochloride

Base Information

• Chemical Name: 1-(4-Piperidyl)-1,2,3,4-tetrahydro-2-quinolinone hydrochloride
• CAS No.: 141134-83-0
• Molecular Formula: C14H18N2O.ClH
• Molecular Weight: 266.76600
• Hs Code.: 2933990090
• Mol file: 141134-83-0.mol

Synonyms:

Chemical Property of 1-(4-Piperidyl)-1,2,3,4-tetrahydro-2-quinolinone hydrochloride

Chemical Property:

• PSA: 32.34000
• LogP: 2.91360

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Piperidyl)-1,2,3,4-tetrahydro-2-quinolinonehydrochloride >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Piperidyl)-1,2,3,4-tetrahydro-2-quinolinone hydrochloride

There total 3 articles about 1-(4-Piperidyl)-1,2,3,4-tetrahydro-2-quinolinone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dihydrocinnamamide (1664-61-5) → 3,4-dihydro-1-(4-piperidyl)-2(1H)-quinoline hydrochloride (141134-83-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, acetic acid / PtO₂ / ethanol

2: 5percent aq. HCl

3: H₂ / Pd/C

With hydrogenchloride; hydrogen; acetic acid; platinum(IV) oxide; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00066a010

Reference yield:

1-(1-Benzyl-piperidin-4-yl)-3,4-dihydro-1H-quinolin-2-one; hydrochloride → 3,4-dihydro-1-(4-piperidyl)-2(1H)-quinoline hydrochloride (141134-83-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; Yield given;

DOI:10.1021/jm00066a010

Reference yield:

3-[2-(1-Benzyl-piperidin-4-ylamino)-phenyl]-propionamide (131587-34-3) → 3,4-dihydro-1-(4-piperidyl)-2(1H)-quinoline hydrochloride (141134-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 5percent aq. HCl

2: H₂ / Pd/C

With hydrogenchloride; hydrogen; palladium on activated charcoal;

DOI:10.1021/jm00066a010

upstream raw materials:

dihydrocinnamamide

3-[2-(1-Benzyl-piperidin-4-ylamino)-phenyl]-propionamide

Refernces