Technology Process of ethyl 5-amino-4-cyano-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate
There total 2 articles about ethyl 5-amino-4-cyano-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
aceanthrenequinone;
With
hydroxylamine hydrochloride; sodium carbonate;
In
ethanol;
for 0.5h;
Reflux;
With
potassium hydroxide;
at 150 - 155 ℃;
for 0.25h;
With
dihydrogen peroxide; acetic acid;
In
water;
for 144h;
DOI:10.1002/chem.200701844
- Guidance literature:
-
With
potassium hydroxide; air;
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
1.) H2O, from 250 to 260 deg C, 90 min, 2.) H2O, heating, 6 h;