5-PROPYL-[1,3,4]THIADIAZOL-2-YLAMINE

Base Information

• Chemical Name: 5-PROPYL-[1,3,4]THIADIAZOL-2-YLAMINE
• CAS No.: 39223-04-6
• Molecular Formula: C5H9N3S
• Molecular Weight: 143.213
• Hs Code.: 2934999090
• Mol file: 39223-04-6.mol

Synonyms:1,3,4-Thiadiazole,2-amino-5-propyl- (6CI);2-Amino-5-propyl-1,3,4-thiadiazole;5-Amino-2-propyl-1,3,4-thiadiazole;5-Propyl-1,3,4-thiadiazole-2-amine;5-Propyl-2-amino-1,3,4-thiadiazole;5-Propyl-[1,3,4]thiadiazol-2-ylamine;

Chemical Property of 5-PROPYL-[1,3,4]THIADIAZOL-2-YLAMINE

Chemical Property:

• Vapor Pressure: 0.00458mmHg at 25°C
• Melting Point: 203 °C(Solv: water (7732-18-5))
• Refractive Index: 1.585
• Boiling Point: 277.2 °C at 760 mmHg
• PKA: 3.84±0.10(Predicted)
• Flash Point: 121.5 °C
• PSA: 80.04000
• Density: 1.224 g/cm³
• LogP: 1.65400

Purity/Quality:

98%min ^*data from raw suppliers

5-Propyl-1,3,4-thiadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 5-PROPYL-[1,3,4]THIADIAZOL-2-YLAMINE

There total 11 articles about 5-PROPYL-[1,3,4]THIADIAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

thiosemicarbazide (79-19-6) + butyric acid (107-92-6) → 5-propyl-1,3,4-thiadiazol-2-ylamine (39223-04-6)

Guidance literature:

With poly(ethylene glycol) supported dichlorophosphate; at 120 ℃; for 0.1h; microwave irradiation;

Reference yield: 76.0%

butyraldehyde (123-72-8) + thiosemicarbazide (79-19-6) → 5-propyl-1,3,4-thiadiazol-2-ylamine (39223-04-6)

Guidance literature:

With tert.-butylhydroperoxide; In ethanol; water; at 20 ℃; for 4h; Green chemistry;

DOI:10.1080/00397911.2017.1398330

Reference yield: 72.0%

trimethylsilyl isothiocyanate (2290-65-5) + butyric acid hydrazide (3538-65-6) → 5-propyl-1,3,4-thiadiazol-2-ylamine (39223-04-6)

Guidance literature:

trimethylsilyl isothiocyanate; butyric acid hydrazide; In ethanol; Reflux;

With sulfuric acid; In ethanol; at 20 ℃;

DOI:10.1039/c3ra00159h

upstream raw materials:

N-(propyl-[1,3,4]thiadiazol-2-yl)-butyramide

1-butyryl-thiosemicarbazide

1,4-dibutyryl thiosemicarbazide

thiosemicarbazide

Downstream raw materials:

[1-Phenyl-meth-(E)-ylidene]-(5-propyl-[1,3,4]thiadiazol-2-yl)-amine

4-(5-propyl-1,3,4-thiadiazole)aminobenzaldehyde

1-(4-Bromo-phenyl)-3-(5-propyl-[1,3,4]thiadiazol-2-yl)-thiourea

1-(4-Methoxy-phenyl)-3-(5-propyl-[1,3,4]thiadiazol-2-yl)-thiourea

Refernces

• 1、 Cao, Lian-Gong,Cao, Zhi-Ling,Chen, Chao,Jiang, Kai-Jun,Liu, Shu-Hao,Liu, Wei-Wei,Ruan, Xin-Chi,Shao, Zhong-Bai,Shi, Da-Hua,Su, Zi-Qin,Wang, You-Xian,Wu, Yu-Ran,Wu, Yu-Yu. "Synthesis of Emodin Amide Derivatives Containing 1,3,4-Thiadiazole and Their Inhibitory Activity on Vibrio harveyi". . p. 281 - 286. Retrieved 2021/08/05.
• 2、 Xue, Wenjie,Li, Xueyao,Ma, Guixing,Zhang, Hongmin,Chen, Ya,Kirchmair, Johannes,Xia, Jie,Wu, Song. "N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification". . . Retrieved 2020/02/04.