rac-10,11,6',7'-tetramethoxy-emetan-2'-carboxylic acid anilide

Base Information

• Chemical Name: rac-10,11,6',7'-tetramethoxy-emetan-2'-carboxylic acid anilide
• CAS No.: 106066-83-5
• Molecular Formula: C₃₆H₄₅N₃O₅
• Molecular Weight: 599.77
• Mol file: 106066-83-5.mol

Synonyms:

Chemical Property of rac-10,11,6',7'-tetramethoxy-emetan-2'-carboxylic acid anilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-10,11,6',7'-tetramethoxy-emetan-2'-carboxylic acid anilide

There total 9 articles about rac-10,11,6',7'-tetramethoxy-emetan-2'-carboxylic acid anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+-)-Emetin (483-18-1,522-99-6,7005-82-5,38241-16-6,65910-27-2,74059-23-7,74111-75-4,74111-76-5) + phenyl isocyanate (103-71-9) → rac-10,11,6',7'-tetramethoxy-emetan-2'-carboxylic acid anilide (106066-83-5,121599-08-4)

Guidance literature:

With diethyl ether;

DOI:10.1002/hlca.19590420513 DOI:10.1002/hlca.19590420714

Reference yield:

phenyl isocyanate (103-71-9) → 10,11,6',7'-tetramethoxy-emetane-2'-carboxylic acid anilide (106066-83-5,121599-08-4)

Guidance literature:

With diethyl ether;

DOI:10.1002/hlca.19590420513

Reference yield:

(+/-)-(3c-ethyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2t-yl)-acetic acid-(3,4-dimethoxy-phenethylamide) (6110-83-4,25858-12-2) → ent-10,11,6',7'-tetramethoxy-emetan-2'-carboxylic acid anilide (106066-83-5,121599-08-4)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃; benzene

2: platinum; methanol / Hydrogenation

3: N-acetyl-L-leucine

4: diethyl ether

With methanol; diethyl ether; N-Ac-Leu; platinum; trichlorophosphate; benzene;

DOI:10.1002/hlca.19590420513

upstream raw materials:

(+)-emetine

phenyl isocyanate

(+/-)-(3c-ethyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2t-yl)-acetic acid-(3,4-dimethoxy-phenethylamide)

(+-)-Emetin