2-anilinoethanethiol

Base Information

• Chemical Name: 2-anilinoethanethiol
• CAS No.: 5977-99-1
• Molecular Formula: C8H11NS
• Molecular Weight: 153.248
• Mol file: 5977-99-1.mol

Synonyms:Ethanethiol, 2-anilino- (6CI,7CI,8CI);2-Anilinoethanethiol;N-(2-Mercaptoethyl)aniline;NSC 68901;b-(Phenylamino)ethanethiol;

Chemical Property of 2-anilinoethanethiol

Chemical Property:

• Vapor Pressure: 0.00359mmHg at 25°C
• Refractive Index: 1.61
• Boiling Point: 281.3 °C at 760 mmHg
• Flash Point: 123.9 °C
• PSA: 50.83000
• Density: 1.098 g/cm³
• LogP: 2.10130

Purity/Quality:

99% ^*data from raw suppliers

2-ANILINOETHANETHIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-anilinoethanethiol

There total 8 articles about 2-anilinoethanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-Anilinoethanol (122-98-5) → 2-(phenylamino)ethanethiol (5977-99-1)

Guidance literature:

With Lawessons reagent; In toluene; for 1h; Reflux;

DOI:10.1021/jo200368a

Reference yield: 54.0%

ethyl 2-mercaptoethyl carbonate (5628-96-6) + aniline (62-53-3) → 2-(phenylamino)ethanethiol (5977-99-1)

Guidance literature:

With sodium methylate; In toluene; at 150 ℃; for 2h;

Reference yield:

aniline (62-53-3) + 2-hydroxyethanethiol (60-24-2) → 2-(2-mercapto-ethylsulfanyl)-ethanol (98026-19-8) + 2-(phenylamino)ethanethiol (5977-99-1)

Guidance literature:

With potassium carbonate; In water; at 120 ℃; for 1h; Microwave irradiation;

DOI:10.1039/c2ra22131d

upstream raw materials:

thirane

aniline

S-(2-anilino-ethyl)-isothiourea; dihydrobromide

N-(β-bromoethyl)aniline hydrobromide

Downstream raw materials:

N-(2-Mercaptoethylthioethyl)anilin

3-phenyl-thiazolidine

2-methyl-3-phenyl-thiazolidine-2-carboxylic acid

2-isobutyl-2-methyl-3-phenyl-thiazolidine

Refernces

• 1、 Banning, Joseph E.,Prosser, Anthony R.,Alnasleh, Bassam K.,Smarker, Jason,Rubina, Marina,Rubin, Michael. "Diastereoselectivity control in formal nucleophilic substitution of bromocyclopropanes with oxygen- and sulfur-based nucleophiles". experimental part. p. 3968 - 3986. Retrieved 2011/07/08.