N-(N-benzyloxycarbonyl-O-methyl-D-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester

Base Information

• Chemical Name: N-(N-benzyloxycarbonyl-O-methyl-D-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester
• CAS No.: 119598-29-7
• Molecular Formula: C₂₇H₃₂N₂O₉
• Molecular Weight: 528.559
• Mol file: 119598-29-7.mol

Synonyms:

Chemical Property of N-(N-benzyloxycarbonyl-O-methyl-D-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-benzyloxycarbonyl-O-methyl-D-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester

There total 6 articles about N-(N-benzyloxycarbonyl-O-methyl-D-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide (4510-09-2) + D-glutamic acid-5-benzyl ester (2578-33-8,1676-73-9,29456-09-5,25014-27-1) → N-(N-benzyloxycarbonyl-O-methyl-L-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester (119598-29-7,124290-65-9,124440-71-7)

Guidance literature:

With diethyl ether; water; potassium hydrogencarbonate; Behandeln des Reaktionsprodukts mit Diazomethan in Methanol;

DOI:10.1016/0040-4020(58)88042-4

Reference yield:

D-glutamic acid-5-benzyl ester (2578-33-8,1676-73-9,29456-09-5,25014-27-1) → N-(N-benzyloxycarbonyl-O-methyl-D-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester (119598-29-7,124290-65-9,124440-71-7)

Guidance literature:

With diethyl ether; water; potassium hydrogencarbonate; Behandeln des ueberwiegend aus N<N-Benzyloxycarbonyl-D-γ-glutamyl>-D-glutaminsaeure-5-benzylester bestehenden Reaktionsprodukts mit Diazomethan in Methanol;

DOI:10.1016/0040-4020(58)88042-4

Reference yield:

D-Glutamic acid (6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → N-(N-benzyloxycarbonyl-O-methyl-L-γ-glutamyl)-D-glutamic acid-5-benzyl ester-1-methyl ester (119598-29-7,124290-65-9,124440-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 - 105 °C

2: diethyl ether; KHCO₃; H₂O / Behandeln des Reaktionsprodukts mit Diazomethan in Methanol

With diethyl ether; water; potassium hydrogencarbonate;

DOI:10.1016/0040-4020(58)88042-4

upstream raw materials:

N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

D-glutamic acid-5-benzyl ester

D-Glutamic acid

benzyl alcohol

Downstream raw materials:

N-(N-benzyloxycarbonyl-O-methyl-L-γ-glutamyl)-5-thio-D-glutamic acid-1-methyl ester-S-phenyl ester

N-(N-benzyloxycarbonyl-O-methyl-L-γ-glutamyl)-D-glutamic acid-1-methyl ester