Benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, chloromethyl ester

Base Information

• Chemical Name: Benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, chloromethyl ester
• CAS No.: 142011-57-2
• Molecular Formula: C14H18ClNO4
• Molecular Weight: 299.754
• Mol file: 142011-57-2.mol

Synonyms:

Chemical Property of Benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, chloromethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, chloromethyl ester

There total 4 articles about Benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, chloromethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-aminomethylbenzoic acid (56-91-7) → chloromethyl 4-(((tert-butoxycarbonyl)amino)methyl)benzoate (142011-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-methyl-propan-2-ol

2: aq. NaHCO₃; [Ch₃(CH₂)3]4N(HSO₄) / CH₂Cl₂

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In dichloromethane; tert-butyl alcohol;

DOI:10.1016/S0960-894X(01)00214-1

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → chloromethyl 4-(((tert-butoxycarbonyl)amino)methyl)benzoate (142011-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-methyl-propan-2-ol

2: aq. NaHCO₃; [Ch₃(CH₂)3]4N(HSO₄) / CH₂Cl₂

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In dichloromethane; tert-butyl alcohol;

DOI:10.1016/S0960-894X(01)00214-1

Reference yield:

chlorosulfuric acid chloromethyl ester (49715-04-0) + 4-(tert-Butoxycarbonylaminomethyl)benzoic acid (33233-67-9) → chloromethyl 4-(((tert-butoxycarbonyl)amino)methyl)benzoate (142011-57-2)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1016/S0960-894X(01)00214-1

upstream raw materials:

chlorosulfuric acid chloromethyl ester

4-(tert-Butoxycarbonylaminomethyl)benzoic acid

p-aminomethylbenzoic acid

di-tert-butyl dicarbonate

Downstream raw materials:

methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate

Refernces

• 1、 Hernandez-Luis, Francisco,Hernandez-Campos, Alicia,Yepez-Mulia, Lilian,Cedillo, Roberto,Castillo, Rafael. "Synthesis and hydrolytic stability studies of albendazole carrier prodrugs". . p. 1359 - 1362. Retrieved 2007/10/03.