2-[(Z)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime

Base Information

• Chemical Name: 2-[(Z)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime
• CAS No.: 125721-15-5
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.217
• Mol file: 125721-15-5.mol

Synonyms:

Chemical Property of 2-[(Z)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(Z)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime

There total 2 articles about 2-[(Z)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bevantolol hydrochloride (42864-78-8) → 2-[(Z)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime (125721-15-5) + 2-[(E)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime (125721-06-4) + 1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-one oxime (125720-97-0) + 1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-one oxime (125720-96-9)

Guidance literature:

With oxalyl dichloride; hydroxylamine hydrochloride; dimethyl sulfoxide; triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, -60 to -40 deg C, 2.) CH₂Cl₂, -40 to -25 deg C, 3.) CH₂Cl₂, H₂O, EtOH, RT,;

DOI:10.1016/S0040-4020(01)81305-3

Reference yield:

Toliprolol hydrochloride (306-11-6) → 2-[(Z)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime (125721-15-5) + 2-[(E)-Hydroxyimino]-3-m-tolyloxy-propionaldehyde oxime (125721-06-4) + 1-Isopropylamino-3-m-tolyloxy-propan-2-one oxime (125720-94-7) + 1-Isopropylamino-3-m-tolyloxy-propan-2-one oxime (125720-95-8)

Guidance literature:

With oxalyl dichloride; hydroxylamine hydrochloride; dimethyl sulfoxide; triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, -60 to -40 deg C, 2.) CH₂Cl₂, -40 to -25 deg C, 3.) CH₂Cl₂, H₂O, EtOH, RT,;

DOI:10.1016/S0040-4020(01)81305-3

upstream raw materials:

bevantolol hydrochloride

Toliprolol hydrochloride

Refernces