Pyrido[1,2-a]benzimidazole (7CI,8CI,9CI)

Base Information

• Chemical Name: Pyrido[1,2-a]benzimidazole (7CI,8CI,9CI)
• CAS No.: 245-47-6
• Molecular Formula: C11H8 N2
• Molecular Weight: 168.198
• Hs Code.: 2933990090
• Mol file: 245-47-6.mol

Synonyms:1,2-Pyrido-4,5-benzo-1,3-diazoline;NSC 660430

Chemical Property of Pyrido[1,2-a]benzimidazole (7CI,8CI,9CI)

Chemical Property:

• Melting Point: 176-177 °C
• Boiling Point: 272.1±22.0 °C(Predicted)
• PKA: 6.80±0.30(Predicted)
• PSA: 17.30000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 2.48750

Purity/Quality:

99% ^*data from raw suppliers

Pyrido[1,2-a]benzimidazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[1,2-a]benzimidazole (7CI,8CI,9CI)

There total 5 articles about Pyrido[1,2-a]benzimidazole (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-(2-methanesulfonylanilino)-pyridine → benzo[4,5]imidazo[1,2-a]pyridine (245-47-6) + α-carboline (244-76-8)

Guidance literature:

In tert-butyl alcohol; for 4h; Irradiation;

Reference yield: 39.0%

[bis(acetoxy)iodo]benzene (3240-34-4) + 2-(phenylamino)pyridine (6631-37-4) → benzo[4,5]imidazo[1,2-a]pyridine (245-47-6) + 2-[(N-acetyl-N-phenyl)amino]pyridine (51263-25-3)

Guidance literature:

With palladium diacetate; acetic acid; In acetic anhydride; at 100 ℃; for 20h;

DOI:10.1021/acs.organomet.9b00113

Reference yield:

[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-pyridin-2-yl-amine → benzo[4,5]imidazo[1,2-a]pyridine (245-47-6) + 8-fluoropyrido[1,2-a]benzimidazole (136343-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / -30 - 50 °C

2: bis(tertbutylcarbonyloxy)iodobenzene / 2.5 h / 25 °C

With bis(tertbutylcarbonyloxy)iodobenzene; In tetrahydrofuran;

DOI:10.1021/ol4015656

upstream raw materials:

N-((4-fluorophenyl)(phenyl)methyl)pyridin-2-amine

2-aminopyridine

[bis(acetoxy)iodo]benzene

2-(phenylamino)pyridine

Downstream raw materials:

N-(2-chlorophenyl)pyridin-2-amine

2-benzimidazolecarboxylic acid

Refernces

• 1、 Liang, Dongdong,He, Yimiao,Liu, Lanying,Zhu, Qiang. "A metal-free tandem demethylenation/C(sp2)-H cycloamination process of N -Benzyl-2-aminopyridines via C-C and C-N bond cleavage". . p. 3476 - 3479. Retrieved 2013/07/26.