methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate

Base Information

• Chemical Name: methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate
• CAS No.: 133-47-1
• Molecular Formula: C6H8O6
• Molecular Weight: 176.12
• Hs Code.: 2918199090
• Mol file: 133-47-1.mol

Synonyms:2-Butenedioicacid, 2,3-dihydroxy-, dimethyl ester, (2E)- (9CI);2-Butenedioic acid,2,3-dihydroxy-, dimethyl ester, (E)-;Fumaric acid, dihydroxy-, dimethyl ester(7CI,8CI);Dimethyl dihydroxyfumarate;

Chemical Property of methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate

Chemical Property:

• Vapor Pressure: 0.000803mmHg at 25°C
• Refractive Index: 1.501
• Boiling Point: 272.1 °C at 760 mmHg
• Flash Point: 110.8 °C
• PSA: 93.06000
• Density: 1.434 g/cm³
• LogP: -0.34000

Purity/Quality:

98%Min ^*data from raw suppliers

Dihydroxyfumaric Acid Dimethyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dihydroxyfumaric Acid Dimethyl Ester is used in the reactions involving of β-sheet formation.

Technology Process of methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate

There total 8 articles about methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,2:2,3:3,4:4,1-tetrakis[propylboranediylbis(oxy)]cyclobutane (86212-11-5) → dimethyl dihydroxyfumarate (133-47-1)

Guidance literature:

In methanol; refluxed for 1 h;

Reference yield: 80.0%

C4(OOBC6H5)2(OCH3)4 (86212-16-0) → dimethyl dihydroxyfumarate (133-47-1)

Guidance literature:

With methanol; In methanol; water; suspn. of the boroxine compd. in CH3OH/H2O was stirred refluxing for 3 h; soln. cooled; filtered;

Reference yield:

methanol (67-56-1) + dihydroxyfumaric acid (133-38-0) → dimethyl dihydroxyfumarate (133-47-1)

Guidance literature:

With hydrogenchloride; at 0 ℃;

upstream raw materials:

diazomethane

dihydroxyfumaric acid

methanol

dimethyl 2,3-dioxobutanedioate

Downstream raw materials:

Dimethyl-bis-(4-chlor-anilino)-maleat

dimethyl oxazole-4,5-dicarboxylate

6-hydroxy-7-oxo-3-phenyl-1,7-dihydro-pyrazolo[1,5-a]pyrimidine-5-carboxylic acid methyl ester

DAF

Refernces

• 1、 -. "BICYCLIC PYRIMIDINONES AND USES THEREOF". Page/Page column 24-25. . Retrieved 2008/12/06.
• 2、 Yalpani, Mohamed,Koester, Roland,Wilke, Guenther. "Hydrated Oxocarbons, I. Preparation and Reactions of Tetrakiscyclobutanes". . p. 1336 - 1344. Retrieved 2007/10/02.