4-Chloro-2-methoxy-5-methylaniline

Base Information

• Chemical Name: 4-Chloro-2-methoxy-5-methylaniline
• CAS No.: 6376-14-3
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Hs Code.: 29222900
• European Community (EC) Number: 228-943-5
• DSSTox Substance ID: DTXSID00213198
• Nikkaji Number: J13.323J
• Wikidata: Q72453157
• Mol file: 6376-14-3.mol

Synonyms:4-chloro-2-methoxy-5-methylaniline;6376-14-3;4-Chloro-5-methyl-o-anisidine;Benzenamine, 4-chloro-2-methoxy-5-methyl-;EINECS 228-943-5;Chlorocresidine;o-Anisidine, 4-chloro-5-methyl-;SCHEMBL92046;DTXSID00213198;4-chloro-2-methoxy-5-methylanilin;STR04175;MFCD00007847;STL168362;AKOS000120073;AC-1937;CCG-302568;4-chloro-2-methoxy-5-methyl-phenylamine;4-Chloro-2-methoxy-5-methylaniline tech.,;CS-0204467;FT-0636126;EN300-20719;D86463;A834513;W-104877;F3098-0019;Z104480222

Chemical Property of 4-Chloro-2-methoxy-5-methylaniline

Chemical Property:

• Appearance/Colour: black crystalline solid
• Vapor Pressure: 0.00535mmHg at 25°C
• Melting Point: 102-103 °C(lit.)
• Refractive Index: 1.565
• Boiling Point: 274.6 °C at 760 mmHg
• Flash Point: 119.9 °C
• PSA: 35.25000
• Density: 1.192 g/cm³
• LogP: 2.82040
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 171.0450916
• Heavy Atom Count: 11
• Complexity: 131

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-methoxy-5-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1Cl)OC)N

Technology Process of 4-Chloro-2-methoxy-5-methylaniline

There total 4 articles about 4-Chloro-2-methoxy-5-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

→ 2-methoxy-5-methyl-4-chloroaniline (6376-14-3)

Guidance literature:

Reference yield:

Cresidine (120-71-8) → 2-methoxy-5-methyl-4-chloroaniline (6376-14-3)

Guidance literature:

With formic acid; at 103 ℃; beim Einleiten von Chlor in eine Loesung des Reaktionsgemisches in Toluol bei 20grad und anschliessenden Erwaermen mit wss. Salzsaeure auf 60grad;

Reference yield:

4-methoxy-3-nitrotoluene (119-10-8) → Cresidine (120-71-8) + 2-methoxy-5-methyl-4-chloroaniline (6376-14-3)

Guidance literature:

With hydrogenchloride; tin;

upstream raw materials:

4-methoxy-3-nitrotoluene

Cresidine

hydrogenchloride

Downstream raw materials:

3,3'-dioxo-3,3'-p-phenylene-di-propionic acid bis-(4-chloro-2-methoxy-5-methyl-anilide)

N-(4-chloro-2-methoxy-5-methyl-phenyl)-anthranilic acid

2,5-dichloro-4-methyl-anisole

C₁₂H₁₇ClN₂O

Refernces