4-(DIMETHYLAMINO)BUT-2-YN-1-OL

Base Information

• Chemical Name: 4-(DIMETHYLAMINO)BUT-2-YN-1-OL
• CAS No.: 14597-26-3
• Molecular Formula: C6H11NO
• Molecular Weight: 113.159
• Hs Code.: 2922199090
• Mol file: 14597-26-3.mol

Synonyms:4-dimethylamino-2-butyn-1-ol;4-dimethylamino-but-2-yn-1-ol;4-Dimethylamino-but-2-in-1-ol;

Chemical Property of 4-(DIMETHYLAMINO)BUT-2-YN-1-OL

Chemical Property:

• Boiling Point: 101 °C(Press: 1.5 Torr)
• PKA: 13.18±0.10(Predicted)
• PSA: 23.47000
• Density: 0.978±0.06 g/cm3(Predicted)
• LogP: -0.45630

Purity/Quality:

99.90% ^*data from raw suppliers

4-(DIMETHYLAMINO)BUT-2-YN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(DIMETHYLAMINO)BUT-2-YN-1-OL

There total 9 articles about 4-(DIMETHYLAMINO)BUT-2-YN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) + propargyl alcohol (107-19-7) → 4-dimethylamino-2-butyn-1-ol (14597-26-3)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium hydroxide; In water; at 80 ℃; for 1h; pH=8;

DOI:10.1016/j.tetlet.2010.04.130

Reference yield: 65.0%

bis-(dimethylamino)methane (51-80-9) + propargyl alcohol (107-19-7) → 4-dimethylamino-2-butyn-1-ol (14597-26-3)

Guidance literature:

With Sm(NO₃)3*6H₂O or Cp₂TiCl₂; at 80 ℃; for 6h; Inert atmosphere; Neat (no solvent);

DOI:10.1134/S1070428011020023

Reference yield:

N,N-Dimethylpropargylamin (7223-38-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 4-dimethylamino-2-butyn-1-ol (14597-26-3)

Guidance literature:

With copper Hydroxide; water; calcium carbonate;

upstream raw materials:

N,N-Dimethylpropargylamin

formaldehyd

4-(dimethylamino)but-2-yn-1-yl acetate

4-chlorobut-2-yn-1-ol

Downstream raw materials:

1-Phenyl-cyclopentan-1-carbonsaeure-(4-dimethylamino-but-2-in-1-yl-ester)

Trimethyl-(4-phenylcarbamoyloxy-but-2-ynyl)-ammonium; iodide

toluene-4-sulphonate(4-hydroxybut-2-ynyl)-N,N,N-trimethylammonium

4-dimethylamino-2-butynyl N-phenylcarbamate

Refernces

• 1、 Chukhadjian,Gabrielyan,Chukhadjian,Shahkhatuni,Panosyan. "Transformations of dialkyl(4-hydroxy-2-butynyl)-(3-phenylallyl)ammonium bromides in an KOH aqueous solution or in the presence of powdered KOH". experimental part. p. 418 - 424. Retrieved 2012/01/13.
• 2、 Kloeckner, Jessica,Schmitz, Jens,Holzgrabe, Ulrike. "Convergent, short synthesis of the muscarinic superagonist iperoxo". experimental part. p. 3470 - 3472. Retrieved 2010/08/20.