2-(2,4-Dichlorophenoxy)propanehydrazide

Base Information

• Chemical Name: 2-(2,4-Dichlorophenoxy)propanehydrazide
• CAS No.: 15253-89-1
• Molecular Formula: C9H10Cl2N2O2
• Molecular Weight: 249.097
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID30370506
• Mol file: 15253-89-1.mol

Synonyms:15253-89-1;2-(2,4-dichlorophenoxy)propanehydrazide;2-(2,4-dichlorophenoxy)propanohydrazide;2-(2,4-Dichlorophenoxy)propionic acid hydrazide;2-(2,4-Dichlorophenoxy)propionicacid hydrazide;Oprea1_822848;SCHEMBL6764780;DTXSID30370506;BBL014251;CCG-55025;MFCD00204152;STK075816;AKOS000283728;AKOS016352206;SB86488;NCGC00326631-01;MS-11276;CS-0312790;FT-0637204;2-[2,4-bis(chloranyl)phenoxy]propanehydrazide;2-(2,4-dichlorophenoxy)Propanoic acid hydrazide;AB01320465-02;A809322;SR-01000003382;Propanoic acid,2-(2,4-dichlorophenoxy)-, hydrazide;SR-01000003382-1;SR-01000003382-2

Chemical Property of 2-(2,4-Dichlorophenoxy)propanehydrazide

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 4.35E-08mmHg at 25°C
• Melting Point: 164-168 °C
• Refractive Index: 1.569
• Boiling Point: 444.2 °C at 760 mmHg
• PKA: 12.05±0.50(Predicted)
• Flash Point: 222.5 °C
• PSA: 64.35000
• Density: 1.381 g/cm³
• LogP: 2.84180
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 248.0119330
• Heavy Atom Count: 15
• Complexity: 228

Purity/Quality:

99% ^*data from raw suppliers

2-(2,4-Dichlorophenoxy)propionic acid hydrazide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)NN)OC1=C(C=C(C=C1)Cl)Cl

Technology Process of 2-(2,4-Dichlorophenoxy)propanehydrazide

There total 3 articles about 2-(2,4-Dichlorophenoxy)propanehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(2,4-dichlorophenoxy)propionate (66423-06-1,66768-02-3,58048-39-8) → 2-(2,4-dichlorophenoxy)propionyl-hydrazine (15253-89-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.0166667h; Microwave irradiation;

DOI:10.1111/j.1747-0285.2011.01205.x

Reference yield:

2,4-dichlorophenol (120-83-2,40477-79-0) → 2-(2,4-dichlorophenoxy)propionyl-hydrazine (15253-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide / N,N-dimethyl-formamide / 0.07 h / Microwave irradiation

2: hydrazine hydrate / ethanol / 0.02 h / Microwave irradiation

With tetrabutylammomium bromide; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1111/j.1747-0285.2011.01205.x

Reference yield:

→ 2-(2,4-dichlorophenoxy)propionyl-hydrazine (15253-89-1)

Guidance literature:

Entspr. Hydrazin, RCOCl;

upstream raw materials:

ethyl 2-(2,4-dichlorophenoxy)propionate

2,4-dichlorophenol

Downstream raw materials:

C₁₅H₁₃Cl₂N₃O₃

C₁₅H₁₃Cl₂N₃O₃

C₁₂H₁₄Cl₂N₂O₃

C₁₆H₁₃Cl₂FN₂O₃

Refernces

• 1、 Liu, Xing-Hai,Pan, Li,Ma, Yi,Weng, Jian-Quan,Tan, Cheng-Xia,Li, Yong-Hong,Shi, Yan-Xia,Li, Bao-Ju,Li, Zheng-Ming,Zhang, Yong-Gang. "Design, Synthesis, Biological Activities, and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2-(2,4-dichlorophenoxy)propane Moiety". experimental part. p. 689 - 694. Retrieved 2012/05/19.