Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-2-(hydroxymethyl)-

Base Information

• Chemical Name: Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-2-(hydroxymethyl)-
• CAS No.: 146796-14-7
• Molecular Formula: C9H8O7S
• Molecular Weight: 260.224
• Mol file: 146796-14-7.mol

Synonyms:2,3-dihydro-2-(hydroxymethyl)thieno[3,4-b]dioxine-5,7-dicarboxylic acid;2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxine-5,7-dicarboxylic acid;

Chemical Property of Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-2-(hydroxymethyl)-

Chemical Property:

• Boiling Point: 547.3±50.0 °C(Predicted)
• PSA: 141.53000
• Density: 1.718±0.06 g/cm3(Predicted)
• LogP: 0.27660

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-2-(hydroxymethyl)-

There total 1 articles about Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-2-(hydroxymethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydroxythiophene-2,5-dicarboxylic acid diethyl ester (1822-66-8) → 2-hydroxymethyl-2,3-dihydrothieno[3,4-b]-[1,4]-dioxin-5,7-dicarboxylic acid (146796-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / K₂CO₃ / ethanol; H₂O / 48 h / Heating

2: 97 percent / KOH, conc. HCl / H₂O

With hydrogenchloride; potassium hydroxide; potassium carbonate; In ethanol; water;

DOI:10.1051/jcp:1998260

Reference yield: 99.4%

2-hydroxymethyl-2,3-dihydrothieno[3,4-b]-[1,4]-dioxin-5,7-dicarboxylic acid (146796-14-7) → (2,3-dihydrothieno[3,4-b][1,4]dioxin-3-yl)methanol (146796-02-3)

Guidance literature:

With copper(II) oxide; In N,N-dimethyl-formamide; at 130 - 132 ℃; for 8h; Inert atmosphere;

upstream raw materials:

3,4-dihydroxythiophene-2,5-dicarboxylic acid diethyl ester

Downstream raw materials:

(2,3-dihydrothieno[3,4-b][1,4]dioxin-3-yl)methanol

Refernces