Chloroacetyl bromide

Base Information

• Chemical Name: Chloroacetyl bromide
• CAS No.: 15018-06-1
• Molecular Formula: C2H2BrClO
• Molecular Weight: 157.394
• DSSTox Substance ID: DTXSID20504313
• Wikidata: Q82358722
• Mol file: 15018-06-1.mol

Synonyms:chloroacetyl bromide;15018-06-1;SCHEMBL225492;DTXSID20504313;LKRZCUQFUCYWLZ-UHFFFAOYSA-N;AKOS006385267

Chemical Property of Chloroacetyl bromide

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 155.89775
• Heavy Atom Count: 5
• Complexity: 44.9

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)Br)Cl

Technology Process of Chloroacetyl bromide

There total 3 articles about Chloroacetyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-bromochloroethylene (17759-85-2) → 2-bromoacetyl chloride (22118-09-8) + chloroacetyl bromide (15018-06-1)

Guidance literature:

Oxydation;

Reference yield:

→ chloroacetyl bromide (15018-06-1) + 1-bromo-2-hexanone (26818-07-5)

Guidance literature:

With chloroform; bromine; at -5 ℃;

DOI:10.1021/ja01297a010

Reference yield:

chloroform (67-66-3,8013-54-5) + chloro-acetic acid-(1-butyl-vinyl ester) (408517-55-5) + bromine (7726-95-6) → chloroacetyl bromide (15018-06-1) + 1-bromo-2-hexanone (26818-07-5)

Guidance literature:

at -5 ℃;

DOI:10.1021/ja01297a010

upstream raw materials:

1,1-bromochloroethylene

chloroform

chloro-acetic acid-(1-butyl-vinyl ester)

bromine

Downstream raw materials:

chloromethyl isocyanate

(bromoacetamidomethyl)-4 clonidine, HBr

N-(chloroacetyl)glycine ethyl ester

O-benzyl chloroacetamido hydroxamic acid