1-(2-thienyl)acetone(SALTDATA: FREE)

Base Information

• Chemical Name: 1-(2-thienyl)acetone(SALTDATA: FREE)
• CAS No.: 15022-18-1
• Molecular Formula: C7H8OS
• Molecular Weight: 140.206
• Hs Code.: 2934999090
• Mol file: 15022-18-1.mol

Synonyms:1-(2-Thienyl)-1,2-propanedione;1-(Thienyl-2)-1,2-propandione;1-(2-Thienyl)propane-1,2-dione;1-(2-thienyl)-2-propanone;1-(thiophen-2-yl)propan-2-one;2-acetonylthiophene;2-thienylacetone;thiophen-2-yl-propan-2-one;1-thiophen-2-yl-propane-1,2-dione;2-acetonylthiphene;2-thenoylacetone;

Chemical Property of 1-(2-thienyl)acetone(SALTDATA: FREE)

Chemical Property:

• Vapor Pressure: 0.287mmHg at 25°C
• Refractive Index: 1.5366 (589.3 nm 13.5℃)
• Boiling Point: 202.8oC at 760 mmHg
• Flash Point: 76.4oC
• PSA: 45.31000
• Density: 1.118g/cm3
• LogP: 1.87960

Purity/Quality:

95%, 99% ^*data from raw suppliers

1-thiophen-2-ylpropan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-thienyl)acetone(SALTDATA: FREE)

There total 26 articles about 1-(2-thienyl)acetone(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tributyl(thien-2-yl)stannane (54663-78-4) + 2-ethoxyallyl diethyl phosphate (112472-96-5) → 1-(thiophen-2-yl)propan-2-one (15022-18-1)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In benzene; react. mixt. washed (aq. KF); extn.of org. layer (ether); dried over MgSO4; product isolated by distn. (reduced pressure); acetonylated by chromy. (silica gel);

DOI:10.1246/bcsj.62.3383

Reference yield: 80.0%

2-isopropenylthiophene (30616-73-0) → 1-(thiophen-2-yl)propan-2-one (15022-18-1)

Guidance literature:

With [hydroxy(tosyloxy)iodo]benzene; In methanol; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2004.06.029

Reference yield: 75.0%

(+/-)-1-(methylthio)-1-(2-thienyl)acetone (84784-36-1) → 1-(thiophen-2-yl)propan-2-one (15022-18-1)

Guidance literature:

With acetic acid; zinc; at 100 ℃; for 1h;

upstream raw materials:

thiophene

diazoacetone

Thiophene-2-acetic acid

acetic acid

Downstream raw materials:

(E)-2-(2-nitroprop-1-en-1-yl)thiophene

α-Methyl-2-thiophenethanol

(+/-)-1-(methyl-2-thien-2-yl)ethylamine

1-hydroxy-1-(thiophene-2-yl)propan-2-one

Refernces

• 1、 Min, R. S.,Aksenov, V. S.,Vinogradov, M. G.,Nikishin, G. I.. "HOMOLYTIC OXOALKYLATION OF FURAN, α-METHYLFURAN, AND THIOPHENE". . p. 1902 - 1907. Retrieved 1981.
• 2、 Albarrán-Velo, Jesús,Gotor-Fernández, Vicente,Lavandera, Iván. "Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols". . p. 4096 - 4108. Retrieved 2021/08/19.
• 3、 Zhu, Zixi,Glinkerman, Christopher M.,Boger, Dale L.. "Selective N1/N4 1,4-Cycloaddition of 1,2,4,5-Tetrazines Enabled by Solvent Hydrogen Bonding". supporting information. p. 20778 - 20787. Retrieved 2020/12/22.