GUGGULSTEROLV

Base Information

• Chemical Name: GUGGULSTEROLV
• CAS No.: 6120-71-4
• Molecular Formula: C29H50 O4
• Molecular Weight: 462.714
• Mol file: 6120-71-4.mol

Synonyms:5a-Cholestane-3b,5,6b-triol, 6-acetate (6CI,7CI,8CI); Guggulsterol V

Chemical Property of GUGGULSTEROLV

Chemical Property:

• PSA: 66.76000
• LogP: 6.12510

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GUGGULSTEROLV

There total 10 articles about GUGGULSTEROLV which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

5α-cholestane-3β,5,6β-triol 3,6-diacetate (1260-68-0) → 3β,5α-dihydroxycholestan-6β-yl acetate (6120-71-4)

Guidance literature:

With potassium hydroxide; In diethyl ether; at 0 ℃; for 3h;

DOI:10.1248/cpb.42.462

Reference yield:

5α-cholestane-3β,5,6β-triol 3,6-diacetate (1260-68-0) → cholestanetriol (1253-84-5) + 3β,5α-dihydroxycholestan-6β-yl acetate (6120-71-4)

Guidance literature:

With methanol; potassium hydroxide; In diethyl ether; at 0 ℃; for 24h; Title compound not separated from byproducts;

Reference yield:

3β-acetoxycholestane-5α,6β-diol (2701-08-8,35089-26-0,98076-44-9,117465-73-3,123285-93-8,1857-99-4) → 3β,5α-dihydroxycholestan-6β-yl acetate (6120-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96.5 percent / 1 h / Heating

2: 97.1 percent / 0.8M methanolic KOH / diethyl ether / 3 h / 0 °C

With potassium hydroxide; In diethyl ether;

DOI:10.1248/cpb.42.462

upstream raw materials:

5α-cholestane-3β,5,6β-triol 3,6-diacetate

ethanol

Cholesteryl acetate

3β-acetoxycholestane-5α,6β-diol

Downstream raw materials:

5α-Cholestan-3β,5α,6β-triol-3-methansulfonat-6-acetat

Refernces

• 1、 Endo,Fukasawa,Hashimoto,Shudo. "Synthesis of oxygenated cholesterols as structural mimics of phorbol ester-type tumor promoters". . p. 462 - 469. Retrieved 2007/10/02.
• 2、 Foster, Richard W.G.,Maples, Brian A.. "Lewis acid-catalyzed rearrangement of steroidal oxetanes: revision of the course of solvolysis of 3β-tosyloxy-5β-cholestan-5-ol-6-one.". . p. 2071 - 2074. Retrieved 2007/10/10.