Benzene, (3-chloro-2-methyl-1-propenyl)-

Base Information

• Chemical Name: Benzene, (3-chloro-2-methyl-1-propenyl)-
• CAS No.: 1507-88-6
• Molecular Formula: C10H11Cl
• Molecular Weight: 166.65
• Mol file: 1507-88-6.mol

Synonyms:

Chemical Property of Benzene, (3-chloro-2-methyl-1-propenyl)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, (3-chloro-2-methyl-1-propenyl)-

There total 12 articles about Benzene, (3-chloro-2-methyl-1-propenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-3-phenyl-2-methyl-2-propenol (1504-55-8,39924-63-5,55131-20-9) → <(E)-3-chloro-2-methyl-1-propenyl>benzene (1507-88-6,55131-21-0)

Guidance literature:

With N-chloro-succinimide; 2,3-dimercapto-succinic acid; In dichloromethane;

DOI:10.1002/anie.200601855

Reference yield: 87.0%

2-methyl-3-phenylprop-2-en-1-ol (1504-55-8) → (3-chloro-2-methyl-1-propenyl)benzene (1507-88-6)

Guidance literature:

With hydrogenchloride; for 1h;

DOI:10.1021/jo00344a013

Reference yield:

2-methyl-3-phenylacrylic acid (1895-97-2) → <(E)-3-chloro-2-methyl-1-propenyl>benzene (1507-88-6,55131-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / LiAlH₄; AlCl₃ / diethyl ether

2: 98 percent / DMS; NCS / CH₂Cl₂

With N-chloro-succinimide; lithium aluminium tetrahydride; aluminium trichloride; 2,3-dimercapto-succinic acid; In diethyl ether; dichloromethane;

DOI:10.1002/anie.200601855

upstream raw materials:

2-methyl-3-phenylprop-2-en-1-ol

2-methyl-1-phenylprop-2-en-1-ol

2-methyl-3-phenyl-2-propenal

ethyl (E)-2-methyl-3-phenyl-2-propenoate

Downstream raw materials:

(E)-2,2,4-trimethyl-5-phenylpent-4-enylamine

C₁₄H₂₁N

2-benzyl-2,4,4-trimethyl-1-(4-methylbenzenesulfonyl)pyrrolidine

(E)-(2-Methyl-3-phenyl-2-propenyl)malonsaeure-diethylester

Refernces

• 1、 Jette, Carina I.,Tong, Z. Jaron,Hadt, Ryan G.,Stoltz, Brian M.. "Copper-Catalyzed Enantioselective Allylic Alkylation with a γ-Butyrolactone-Derived Silyl Ketene Acetal". supporting information. p. 2033 - 2038. Retrieved 2020/01/02.
• 2、 Jiang, Tao,Huynh, Khoi,Livinghouse, Tom. "Substrate structural effects in yttrium(III)-catalyzed hydroamination/ cyclizations of 1,2-disubstituted and 1,1,2-trisubstituted aminoalkenes terminated by 2-(phenyl) and 2-(2-heteroarenyl) groups". supporting information. p. 193 - 196. Retrieved 2013/03/13.