4-Aminopyridazine

Base Information

• Chemical Name: 4-Aminopyridazine
• CAS No.: 20744-39-2
• Molecular Formula: C4H5N3
• Molecular Weight: 95.1038
• Hs Code.: 2933990090
• European Community (EC) Number: 692-025-4
• NSC Number: 170657
• UNII: 2H2SSX4YHL
• DSSTox Substance ID: DTXSID90305399
• Nikkaji Number: J83.010K,J845.841C
• Wikidata: Q72441454
• Mol file: 20744-39-2.mol

Synonyms:4-aminopyridazine;pyridazin-4-amine;20744-39-2;4-Pyridazinamine;pyridazin-4-ylamine;Pyridazine, 4-amino-;MFCD00233975;2H2SSX4YHL;NSC-170657;pyridazine-4-amine;NSC170657;pyridazin-4-yl-amine;UNII-2H2SSX4YHL;4-Aminopyridazine, 97%;4-Aminopyridazine, AldrichCPR;DTXSID90305399;BCP27543;BBL101079;STL554873;AKOS005256693;CS-W007757;PB29051;PS-9354;AC-23844;SY008183;A4503;AM20090167;FT-0617605;EN300-72823;W-206553

Chemical Property of 4-Aminopyridazine

Chemical Property:

• Appearance/Colour: Light yellow powder
• Vapor Pressure: 0.000219mmHg at 25°C
• Melting Point: 127-133°C
• Refractive Index: 1.598
• Boiling Point: 326.2 °C at 760 mmHg
• PKA: 6.38±0.10(Predicted)
• Flash Point: 177.3 °C
• PSA: 51.80000
• Density: 1.216 g/cm³
• LogP: 0.64000
• Storage Temp.: ?20°C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 95.048347172
• Heavy Atom Count: 7
• Complexity: 54.9

Purity/Quality:

99% ^*data from raw suppliers

4-Pyridazinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=NC=C1N
• Uses: 4-Pyridazinamine is used to prepare phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition. It is also used to synthesize ATP competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors.

Technology Process of 4-Aminopyridazine

There total 8 articles about 4-Aminopyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,6-dichloropyridazin-4-amine (823-58-5) → 4-aminopyridazine (20744-39-2)

Guidance literature:

With sodium hydroxide; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; water; at 20 ℃; for 48h;

Reference yield: 91.0%

1,2-diazine (289-80-5) → 4-aminopyridazine (20744-39-2)

Guidance literature:

With potassium permanganate; potassium amide; In ammonia; for 0.166667h;

Reference yield:

3,4,5-trichloropyridazine (14161-11-6) → 4-aminopyridazine (20744-39-2)

Guidance literature:

With sodium hydroxide; palladium; In ethanol; ethyl acetate;

upstream raw materials:

3,6-dichloropyridazin-4-amine

5-amino-3,4-dichloropyridazine

(3,5-dichloropyridazin-4-yl)amine

1,2-diazine

Downstream raw materials:

5-chloropyridazin-4-ylamine

Refernces

• 1、 -. "NOVEL COMPOUNDS". Page/Page column 52. . Retrieved 2011/04/25.
• 2、 -. "1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO". Page/Page column 175-176. . Retrieved 2010/02/11.