Methyl 2-ethylisonicotinate

Base Information

• Chemical Name: Methyl 2-ethylisonicotinate
• CAS No.: 1531-16-4
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2933399090
• Mol file: 1531-16-4.mol

Synonyms:methyl 2-ethyl hexanoate;2-Aethyl-hexansaeure-methylester;Methyl-2-Butyl-Butyrate;methyl 2-ethylpyridine-4-carboxylate;Hexanoic acid,2-ethyl-,methyl ester;2-ethyl-isonicotinic acid methyl ester;2-Ethylisonicotinsaeure-methylester;2-ethyl-hexanoic acid methyl ester;2-Aethyl-isonicotinsaeure-methylester;

Chemical Property of Methyl 2-ethylisonicotinate

Chemical Property:

• PSA: 39.19000
• LogP: 1.43060

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl 2-ethylisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2-ethylisonicotinate

There total 9 articles about Methyl 2-ethylisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

ethyl bromide (74-96-4) + methyl 2-chloroisonicotinate (58481-11-1) → methyl 2-ethylpyridine-4-carboxylate (1531-16-4)

Guidance literature:

ethyl bromide; With magnesium; In diethyl ether; Reflux;

methyl 2-chloroisonicotinate; With iron(III)-acetylacetonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; at 20 ℃; for 2h;

DOI:10.1021/jm1008727

Reference yield: 42.0%

2-allyl-4-ethyl-2-(toluene-4-sulfonyl)-pent-4-enoic acid methyl ester (851762-26-0) → methyl 2-ethylpyridine-4-carboxylate (1531-16-4)

Guidance literature:

2-allyl-4-ethyl-2-(toluene-4-sulfonyl)-pent-4-enoic acid methyl ester; With ozone; In methanol; dichloromethane; at -78 ℃;

With triphenylphosphine; In methanol; dichloromethane; at -78 - 20 ℃;

With ammonia; In methanol; ethanol; dichloromethane; at 20 ℃;

DOI:10.1016/j.tetlet.2005.02.105

Reference yield:

ethionamide (536-33-4,5261-38-1) → 2-ethyl-4-pyridinecarbonitrile (1531-18-6) + 2-ethylpyridine-4-carboxylic acid (3376-96-3) + 2-ethylpyridine-4-carboxamide (3376-95-2) + methyl 2-ethylpyridine-4-carboxylate (1531-16-4) + ethionamide S-oxide + C16H20N4

Guidance literature:

With Oxone; In methanol; water; at 20 ℃; for 0.0833333h;

DOI:10.1039/c6ob01561a

upstream raw materials:

2-ethyl-6-chloro-isonicotinic acid methyl ester

2-allyl-4-ethyl-2-(toluene-4-sulfonyl)-pent-4-enoic acid methyl ester

methyl 2-(toluene-4-sulfonyl)pent-4-enoate

2-chloro-6-ethylpyridine-4-carboxylic acid

Downstream raw materials:

2-ethyl-4-(bromomethyl)pyridine

ethionamide

2-ethyl-4-pyridinecarbonitrile

2-ethylpyridine-4-carboxamide

Refernces

• 1、 -. "SUBSTITUTED BENZAMIDE DERIVATIVES". Page/Page column 97. . Retrieved 2013/02/27.
• 2、 Craig, Donald,Henry, Gavin D.. "Sulfone-mediated synthesis of polysubstituted pyridines". . p. 2559 - 2562. Retrieved 2007/10/03.