2-iodo-4-methylquinoline

Base Information

• Chemical Name: 2-iodo-4-methylquinoline
• CAS No.: 607-65-8
• Molecular Formula: C10H8 I N
• Molecular Weight: 269.085
• Mol file: 607-65-8.mol

Synonyms:NSC 3883

Chemical Property of 2-iodo-4-methylquinoline

Chemical Property:

• Vapor Pressure: 0.000191mmHg at 25°C
• Boiling Point: 338.5°C at 760 mmHg
• Flash Point: 158.5°C
• Density: 1.734g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-iodo-4-methylquinoline

There total 3 articles about 2-iodo-4-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methylquinolin-2-yl trifluoromethanesulfonate (108530-09-2) → 2-iodo-4-methylquinoline (607-65-8)

Guidance literature:

With acetyl chloride; sodium iodide; In acetonitrile; at 18 - 80 ℃; Microwave irradiation;

DOI:10.1021/jo9008386

Reference yield: 93.0%

2-chloro-4-methylquinoline (634-47-9) → 2-iodo-4-methylquinoline (607-65-8)

Guidance literature:

With hydrogen iodide; sodium iodide; In butanone; for 24h; Heating;

Reference yield: 92.0%

4-methylquinolin-2-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (93131-77-2) → 2-iodo-4-methylquinoline (607-65-8)

Guidance literature:

With acetyl chloride; sodium iodide; In acetonitrile; at 18 - 80 ℃; Microwave irradiation;

DOI:10.1021/jo9008386

upstream raw materials:

2-chloro-4-methylquinoline

4-methylquinolin-2-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

4-methylquinolin-2-yl trifluoromethanesulfonate

Downstream raw materials:

4-methyl-2-[(1E)-2-phenylethenyl]quinoline

2,2′-biquinoline-4,4′-dicarboxylic acid

ethyl 4-methyl-2-quinolineacetate

(E)-4-methyl-2-quinolineacrylonitrile

Refernces

• 1、 Sakamoto, Takao,Arakida, Hiroko,Edo, Kiyoto,Yamanaka, Hiroshi. "Studies on Pyrimidine Derivatives. XXX. The Palladium-Catalyzed Cross-Coupling Reaction of Iodopyrimidines with Terminal Olefinic Compounds". . p. 3647 - 3656. Retrieved 2007/10/02.