Cyclohex-2-enaMine

Base Information

• Chemical Name: Cyclohex-2-enaMine
• CAS No.: 1541-25-9
• Molecular Formula: C6H11N
• Molecular Weight: 97.16
• Mol file: 1541-25-9.mol

Synonyms:Cyclohex-2-enylamin;2-cyclohexenyl phenyl selenide;3-amino-1-cyclohexene;cyclohex-2-enamine;cyclohexen-3-yl phenyl selenide;3-phenylseleno-1-cyclohexene;cyclohexen-3-ylamine;cyclohex-2-enylamine;cyclohex-2-enyl phenyl selenide;2-cyclohexenylamine;3-phenylselanylcyclohex-1-ene;2-cyclohexen-1-amine;

Chemical Property of Cyclohex-2-enaMine

Chemical Property:

• Boiling Point: 137-138 °C
• PKA: 10.31±0.20(Predicted)
• PSA: 26.02000
• Density: 0.905±0.06 g/cm3(Predicted)
• LogP: 1.75410

Purity/Quality:

99%, ^*data from raw suppliers

2-cyclohexen-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohex-2-enaMine

There total 30 articles about Cyclohex-2-enaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-(cyclohex-2-enyl) methyl carbamate (86766-64-5) → 3-amino-1-cyclohexene (1541-25-9)

Guidance literature:

With potassium hydroxide; In methanol; water; for 24h; Heating;

DOI:10.1021/jo00168a040

Reference yield: 70.0%

2-Cyclohexenyl-isothiocyanat (2696-79-9) → 3-amino-1-cyclohexene (1541-25-9)

Guidance literature:

With 3,4-dimercaptotoluene; In methanol;

DOI:10.1016/S0040-4039(00)92512-7

Reference yield: 67.0%

1-(2-cyclohexen-1-yl)-4-methyl-2-(2-oxo-2-phenylethyl)-1,2,4-triazolidine-3,5-dione (270063-67-7) → 3-amino-1-cyclohexene (1541-25-9)

Guidance literature:

With potassium hydroxide; In methanol; water; at 80 - 155 ℃;

DOI:10.1021/ol000044c

upstream raw materials:

1,2-dibromocyclohexane

rac-3-bromocyclohexene

2-cyclohex-2-enyl-isoindole-1,3-dione

2-Cyclohexenyl-isothiocyanat

Downstream raw materials:

N-(Cyclohex-2-enyl)-α,β,β,β-tetrafluoropropionamid

(+/-)-trans-2-aminocyclohexanol

N-cyclohex-2-enyl-2,2,2-trifluoro-acetamide

Cyclohex-2-enyl-ethyl-((E)-penta-2,4-dienyl)-amine

Refernces

• 1、 Cosgrove, Sebastian C.,Grogan, Gideon,Mangas-Sanchez, Juan,Marshall, James R.,Palmer, Ryan B.,Ramsden, Jeremy I.,Sharma, Mahima,Thorpe, Thomas W.,Turner, Nicholas J.. "Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases". . p. 5052 - 5057. Retrieved 2020/06/09.
• 2、 Lu, Hongfu,Yang, Ting,Xu, Zhongmiao,Lin, Xichen,Ding, Qian,Zhang, Yueting,Cai, Xin,Dong, Kelly,Gong, Sophie,Zhang, Wei,Patel, Metul,Copley, Royston C. B.,Xiang, Jianing,Guan, Xiaoming,Wren, Paul,Ren, Feng. "Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists". . p. 2518 - 2532. Retrieved 2018/03/26.