4-Chloro-3-methylanisole

Base Information

• Chemical Name: 4-Chloro-3-methylanisole
• CAS No.: 13334-71-9
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.612
• Hs Code.: 29093038
• Mol file: 13334-71-9.mol

Synonyms:Anisole,4-chloro-3-methyl- (7CI,8CI);1-Chloro-2-methyl-4-methoxybenzene;1-Chloro-4-methoxy-2-methylbenzene;2-Chloro-5-methoxytoluene;3-Methyl-4-chloroanisole;4-Chloro-3-methylanisole;

Chemical Property of 4-Chloro-3-methylanisole

Chemical Property:

• Appearance/Colour: clear colourless liquid
• Vapor Pressure: 0.255mmHg at 25°C
• Refractive Index: 1.534-1.536
• Boiling Point: 212.2 °C at 760 mmHg
• Flash Point: 87.9 °C
• PSA: 9.23000
• Density: 1.105 g/cm³
• LogP: 2.65700
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-3-methylanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-Chloro-3-methylanisole

There total 11 articles about 4-Chloro-3-methylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-methoxy-3-methyl-benzene (100-84-5) → 1-chloro-4-methoxy-2-methylbenzene (13334-71-9)

Guidance literature:

With N-chloro-succinimide; 2,4,6-trimethylaniline; In dichloromethane; at 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201502234

Reference yield: 93.0%

4-Chloro-3-methylphenol (59-50-7) + carbonic acid dimethyl ester (616-38-6) → 1-chloro-4-methoxy-2-methylbenzene (13334-71-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 220 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/op200379j

Reference yield: 85.2%

4-Chloro-3-methylphenol (59-50-7) + methyl iodide (74-88-4) → 1-chloro-4-methoxy-2-methylbenzene (13334-71-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Reagent/catalyst; Solvent;

upstream raw materials:

3-chloro-6-methoxy-2-methyl-aniline

4-Chloro-3-methylphenol

dimethyl sulfate

methyl iodide

Downstream raw materials:

4-(5-chloro-2-methoxy-4-methyl-phenyl)-4-oxo-butyric acid

4-phenylamino-3-methyl-1-methoxybenzene

N-(4-methoxy-2-methylbenzyl)morpholine

4-methoxy-2-methyl-N-octylaniline

Refernces

• 1、 Samanta, Ramesh C.,Yamamoto, Hisashi. "Selective Halogenation Using an Aniline Catalyst". supporting information. p. 11976 - 11979. Retrieved 2015/08/18.
• 2、 Tilstam, Ulf. "A continuous base-catalyzed methylation of phenols with dimethyl carbonate". experimental part. p. 1150 - 1153. Retrieved 2012/08/27.